Benzonitrile, 5-broMo-2,3-difluoro-

Base Information

• Chemical Name: Benzonitrile, 5-broMo-2,3-difluoro-
• CAS No.: 1105665-42-6
• Molecular Formula: C7H2BrF2N
• Molecular Weight: 218
• Hs Code.: 2926907090
• Mol file: 1105665-42-6.mol

Synonyms:Benzonitrile, 5-broMo-2,3-difluoro-;5-Bromo-2,3-difluorobenzonitrile

Chemical Property of Benzonitrile, 5-broMo-2,3-difluoro-

Chemical Property:

• Boiling Point: 215.6±35.0 °C(Predicted)
• PSA: 23.79000
• Density: 1.77±0.1 g/cm3(Predicted)
• LogP: 2.59898
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2,3-difluorobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzonitrile, 5-broMo-2,3-difluoro-

There total 7 articles about Benzonitrile, 5-broMo-2,3-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-amino-2,3-difluorobenzonitrile (1247885-41-1) → 5-bromo-2,3-difluorobenzonitrile (1105665-42-6)

Guidance literature:

With tert.-butylnitrite; copper(I) bromide; In acetonitrile; at 0 - 20 ℃;

Reference yield: 91.0%

5-bromo-2,3-difluorobenzaldehyde (633327-22-7) → 5-bromo-2,3-difluorobenzonitrile (1105665-42-6)

Guidance literature:

With ammonium hydroxide; iodine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 90.0%

5-bromo-2,3-difluorobenzamide → 5-bromo-2,3-difluorobenzonitrile (1105665-42-6)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; at 20 ℃; for 4.5h; Cooling with ice;

upstream raw materials:

5-amino-2,3-difluorobenzonitrile

2,3-difluorobenzonitrile

2,3-difluoro-5-nitrobenzonitrile

5-bromo-2,3-difluorobenzaldehyde

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME". Paragraph 0827-0828. . Retrieved 2020/12/08.
• 2、 -. "COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF". Page/Page column 237. . Retrieved 2010/11/03.