2-Pyridineacetic acid, a,a-difluoro-

Base Information

• Chemical Name: 2-Pyridineacetic acid, a,a-difluoro-
• CAS No.: 1039621-73-2
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.119
• Hs Code.: 2933399990
• Mol file: 1039621-73-2.mol

Synonyms:2-Pyridineacetic acid, a,a-difluoro-;2-[Carboxy(difluoro)methyl]pyridine , 2,2-Difluoro-2-(pyridin-2-yl)ethanoic acid;2,2-difluoro-2-pyridin-2-ylacetic acid;2,2-difluoro-2-(2-pyridyl)acetic acid

Chemical Property of 2-Pyridineacetic acid, a,a-difluoro-

Chemical Property:

• PSA: 50.19000
• LogP: 1.25800
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Difluoro(pyridin-2-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridineacetic acid, a,a-difluoro-

There total 5 articles about 2-Pyridineacetic acid, a,a-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 2,2-difluoro-2-(pyridin-2-yl)acetic acid (1039621-73-2)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 94.0%

ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate (267876-28-8) → 2,2-difluoro-2-(pyridin-2-yl)acetic acid (1039621-73-2)

Guidance literature:

With lithium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.jfluchem.2021.109792

Reference yield: 20.0%

2-iodopyridine (5029-67-4) + Ethyl bromodifluoroacetate (667-27-6) → 2,2-difluoro-2-(pyridin-2-yl)acetic acid (1039621-73-2)

Guidance literature:

2-iodopyridine; Ethyl bromodifluoroacetate; With copper; In dimethyl sulfoxide; at 60 ℃; for 12h;

With potassium carbonate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/acs.orglett.6b01188

upstream raw materials:

2-iodopyridine

Ethyl bromodifluoroacetate

ethyl 2-(pyridinyl-2)acetate

ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate

Refernces

• 1、 -. "Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole". Paragraph 0055-0062; 0070. . Retrieved 2020/12/30.
• 2、 Chen, Fei,Hashmi, A. Stephen K.. "Silver-Catalyzed Decarboxylative Alkynylation of α,α-Difluoroarylacetic Acids with Ethynylbenziodoxolone Reagents". supporting information. p. 2880 - 2882. Retrieved 2016/07/06.