267876-28-8

Basic information

• Product Name: ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE
• Synonyms: ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE;ETHYL DIFLUORO(PYRIDIN-2-YL)ACETATE;2-Pyridineacetic acid, a,a-difluoro-, ethyl ester;Difluoro(pyridin-2-yl)acetic acid ethyl ester, 2-(1,1-Difluoro-2-ethoxy-2-oxoethyl)pyridine;Ethyl 2,2-Difluoro-2-(pyridin-2-yl)acetate
• CAS NO: 267876-28-8
• Molecular Formula: C₉H₉F₂NO₂
• Molecular Weight: 201.17
• Product Categories: pharmacetical
• Mol File: 267876-28-8.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 244.162 °C at 760 mmHg
• Flash Point: 101.466 °C
• Appearance: /
• Density: 1.229 g/cm³
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: 2-8°C
• PKA: 1.80±0.12(Predicted)
• CAS DataBase Reference: ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE(267876-28-8)
• EPA Substance Registry System: ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE(267876-28-8)

Safety Data

• Hazard Codes: F
• Hazardous Substances Data: 267876-28-8(Hazardous Substances Data)

Usage

General Description

ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE is a chemical compound that belongs to the class of pyridyl acetates. It is a colorless liquid with a fruity odor, and it is soluble in organic solvents. ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis, particularly in the preparation of fluoroalkylated compounds. Additionally, it has potential applications in the development of new materials and in medicinal chemistry for the treatment of various diseases. Nonetheless, ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE should be handled with care, as it may be harmful if ingested, inhaled, or comes into contact with the skin.

InChI:InChI=1/C9H9F2NO2/c1-2-14-8(13)9(10,11)7-5-3-4-6-12-7/h3-6H,2H2,1H3

Upstream product

• 109-04-6 2-bromo-pyridine 
• 667-27-6 Ethyl bromodifluoroacetate 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 
• 110-86-1 pyridine 
• 7648-30-8 ethyl 2,2-difluoro-2-iodoacetate 
• 5029-67-4 2-iodopyridine 
• 55104-63-7 ethyl 2-(pyridin-2-yl)-2-oxoacetate 
• 12775-96-1 copper 
• 38078-09-0 diethylamino-sulfur trifluoride 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 

Downstream Products

• 294182-05-1 2,2-difluoro-1-(2,4-difluorophenyl)2-(2-pyridyl)ethanone 
• 267875-68-3 2.2-Difluoro-2-(pyridin-2-yl)ethylamine 
• 1039621-73-2 2,2-difluoro-2-(pyridin-2-yl)acetic acid 
• 1416733-53-3 2-(2,4-difluorophenyl)-1,1-difluoro-1-(pyridin-2-yl)-3-(thiazol-5-yl)propan-2-ol 
• 1416733-54-4 C₁₇H₁₁ClF₄N₂OS 
• 1416732-20-1 2-(2,4-difluorophenyl)-1,1-difluoro-1-(pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol 
• 1416733-14-6 C₁₇H₁₅F₄N₅O 
• 1416733-13-5 C₁₇H₁₁F₄N₃O 
• 1416733-12-4 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-4-yl)-1-(pyridin-2-yl)propan-2-ol 
• 1299945-50-8 2,2-difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate 
• 435345-04-3 2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt 
• 267875-65-0 2,2-difluoro-2-(pyridin-2-yl)-ethan-1-ol 
• 294182-27-7 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]pyridine 

Relevant articles and documents

Copper-mediated reaction of 2-halopyridines with ethyl bromodifluoroacetate

A facile process for the preparation of substituted ethyl 2′-pyridyldifluoroacetates 3 is described starting from readily available ethyl bromodifluoroacetate 2 and substituted 2-bromo or 2-chloropyridines 1. This process features a copper-mediated cross-coupling reaction in DMSO and is the first to utilise pyridylbromides or chlorides with ethyl bromodifluoroacetate 2 in this reaction.

Method for catalyzing ethoxycarbonyldifluoromethylation of aromatic compound by iron

The invention discloses a method for catalyzing ethoxycarbonyldifluoromethylation of an aromatic compound by iron, which comprises the following steps of: in a solvent, with ethyl halodifluoroacetate as a fluorine reagent, peroxide as an oxidant, iron as

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.