tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate

Base Information

• Chemical Name: tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate
• CAS No.: 1016971-66-6
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• European Community (EC) Number: 689-641-0,825-732-5
• DSSTox Substance ID: DTXSID80589247
• Nikkaji Number: J2.397.241G
• Wikidata: Q76511672
• Mol file: 1016971-66-6.mol

Synonyms:1016971-66-6;tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate;(1R,2R)-trans-N-Boc-1,2-cyclopentanediamine;tert-butyl N-[(1R,2R)-2-aminocyclopentyl]carbamate;365996-21-0;tert-butyl (1R,2R)-2-aminocyclopentylcarbamate;Carbamic acid, N-[(1R,2R)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester;tert-Butyl [(1R,2R)-2-aminocyclopentyl]carbamate;MFCD11040591;Carbamic acid, [(1R,2R)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester, rel-;(1R,2R)-Boc-1,2-diaminocyclopentane;SCHEMBL741725;DTXSID80589247;PAXDIBGWURAVIH-HTQZYQBOSA-N;MFCD12197287;AKOS026676652;AT11486;trans-1-(Boc-amino)-2-aminocyclopentane;AS-79593;DB-335484;CS-0187991;CS-0368621;(1R,2R)-1-(Boc-amino)-2-aminocyclopentane;EN300-60057;t-Butyl N-[trans-2-aminocyclopentyl]carbamate;EN300-244890;F53311;tert-Butyl (1R*,2R*)-2-aminocyclopentylcarbamate;tert-Butyl(1R*,2R*)-2-aminocyclopentylcarbamate;J-000477;J-524335;tert-butylN-[(1R,2R)-2-aminocyclopentyl]carbamate;trans-N-tert-Butoxycarbonyl-1,2-cyclopentanediamine;(1R,2R)-trans-N-Boc-1,2-cyclopentanediamine, 98%;rel-tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate;trans-N-tert-Butoxycarbonyl-1,2-cyclopentane-diamine;TRANS-TERT-BUTYL (2-AMINOCYCLOPENTYL)CARBAMATE;F8889-8691;rac-tert-butyl N-[(1R,2R)-2-aminocyclopentyl]carbamate;(+/-)-trans-N-tert-Butoxycarbonyl-1,2-cyclopentanediamine;(1R*,2R*)-2-aminocyclopentylcarbamic acid tert-butyl ester;(+/-)-trans-N-tert-Butoxycarbonyl-1,2-cyclopentane-diamine

Chemical Property of tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate

Chemical Property:

• PSA: 67.84000
• LogP: 2.29560
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 200.152477885
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

97% ^*data from raw suppliers

(1R,2R)-trans-N-Boc-1,2-cyclopentanediamine 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1CCCC1N
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H]1CCC[C@H]1N
• Uses: (1R,2R)-trans-N-Boc-1,2-cyclopentanediamine can be used as a starting material in the synthesis of novel helical oligomers of biological importance.

Technology Process of tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate

There total 20 articles about tert-Butyl ((1R,2R)-2-aminocyclopentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C17H26N2O4S → tert-butyl ((1R,2R)-2-aminocyclopentyl)carbamate (1016971-66-6,1193388-07-6,365996-21-0)

Guidance literature:

With naphthalene; lithium; In 1,2-dimethoxyethane; at 0 ℃; for 5.33333h; Inert atmosphere;

Reference yield: 51.0%

tert-butyl rac-trans-(2-aminocyclopentyl)carbamate (1193388-07-6,365996-21-0) → (-)-(1S,2S)-N-mono(tert-butoxycarbonyl) cyclopentane-1,2-diamine (586961-34-4,1193388-07-6,365996-21-0) + tert-butyl ((1R,2R)-2-aminocyclopentyl)carbamate (1016971-66-6,1193388-07-6,365996-21-0)

Guidance literature:

DOI:10.1021/jo061409v

Reference yield:

tert-butyl (1R,2R)-2-(benzyloxycarbonylamino)cyclopentylcarbamate (815645-30-8) → tert-butyl ((1R,2R)-2-aminocyclopentyl)carbamate (1016971-66-6,1193388-07-6,365996-21-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 2844.31 Torr;

DOI:10.1021/ja046280q

upstream raw materials:

tert-butyl (1R,2R)-2-(benzyloxycarbonylamino)cyclopentylcarbamate

tert-butyl rac-trans-(2-aminocyclopentyl)carbamate

di-tert-butyl dicarbonate

(1R,2R)-2-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid