1-(4-CHLOROPHENYL)-2-NITROPROPENE

Base Information

• Chemical Name: 1-(4-CHLOROPHENYL)-2-NITROPROPENE
• CAS No.: 37629-52-0
• Molecular Formula: C9H8ClNO2
• Molecular Weight: 197.621
• Mol file: 37629-52-0.mol

Synonyms:4'-CHLORO-BETA-METHYL-BETA-NITROSTYRENE;1-(4-CHLOROPHENYL)-2-NITROPROPENE

Chemical Property of 1-(4-CHLOROPHENYL)-2-NITROPROPENE

Chemical Property:

• Vapor Pressure: 0.00162mmHg at 25°C
• Boiling Point: 304°C at 760 mmHg
• Flash Point: 137.6°C
• PSA: 45.82000
• Density: 1.275g/cm³
• LogP: 3.50070

Purity/Quality:

97% ^*data from raw suppliers

1-chloro-4-[(1E)-2-nitroprop-1-en-1-yl]benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-CHLOROPHENYL)-2-NITROPROPENE

There total 6 articles about 1-(4-CHLOROPHENYL)-2-NITROPROPENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Nitroethane (79-24-3) + 4-chlorobenzaldehyde (104-88-1) → (E)-1-(4-chlorophenyl)-2-nitropropene (37629-52-0)

Guidance literature:

MCM-41-NH₂; at 90 ℃; for 6h;

DOI:10.1016/S0040-4039(01)00156-3

Reference yield: 95.0%

1-(4-chlorophenyl)-2-nitro-propan-1-ol (27852-91-1) → (E)-1-(4-chlorophenyl)-2-nitropropene (37629-52-0)

Guidance literature:

With triethylamine; triphenylphosphine; In tetrachloromethane; for 2h; Heating;

DOI:10.1055/s-1994-25546

Reference yield: 80.0%

Nitroethane (79-24-3) + 4-chlorobenzaldehyde (104-88-1) → 3,5-dimethyl-4-(4-chlorophenyl)-isoxazole + 1-(4-chlorophenyl)-2-nitro-propan-1-ol (27852-91-1) + (E)-1-(4-chlorophenyl)-2-nitropropene (37629-52-0)

Guidance literature:

With CsNaX zeolite; for 24h; Heating;

DOI:10.1006/jcat.1999.2759

upstream raw materials:

Nitroethane

4-chlorobenzaldehyde

1-(4-chlorophenyl)-2-nitro-propan-1-ol

para-Chlorobenzyl alcohol

Downstream raw materials:

4-(4-chlorophenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide

Refernces

• 1、 Akula, Pavan Sudheer,Hong, Bor-Cherng,Lee, Gene-Hsiang. "Catalyst- and Substituent-Controlled Switching of Chemoselectivity for the Enantioselective Synthesis of Fully Substituted Cyclobutane Derivatives via 2 + 2 Annulation of Vinylogous Ketone Enolates and Nitroalkene". supporting information. p. 7835 - 7839. Retrieved 2019/01/04.
• 2、 Manoni, Francesco,Farid, Umar,Trujillo, Cristina,Connon, Stephen J.. "Catalytic asymmetric Tamura cycloadditions involving nitroalkenes". . p. 1463 - 1474. Retrieved 2017/02/15.