Technology Process of Odalasvir
There total 9 articles about Odalasvir which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C46H50N6*4CH4O3S;
With
triethylamine;
In
dichloromethane;
at 10 ℃;
for 0.5h;
Industrial scale;
N-methoxycarbonyl-L-valine;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dichloromethane;
at 10 - 25 ℃;
for 3.5h;
Industrial scale;
DOI:10.1021/acs.oprd.1c00237
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid / ethyl acetate; tetrahydrofuran / 8 - 69 °C / Industrial scale
2.1: potassium acetate; [2,6-bis(2,4,6-triisopropylphenyl)phenyl(dicyclohexylphosphine)](allyl-η3)palladium(II) chloride / Isopropyl acetate / 5 h / 90 °C / Industrial scale
3.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tetrabutylammomium bromide; caesium carbonate / water; toluene / 17 h / 90 °C / Inert atmosphere; Industrial scale
4.1: dichloromethane / 11 h / 20 - 35 °C / Reflux; Industrial scale
5.1: triethylamine / dichloromethane / 0.5 h / 10 °C / Industrial scale
5.2: 3.5 h / 10 - 25 °C / Industrial scale
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; [2,6-bis(2,4,6-triisopropylphenyl)phenyl(dicyclohexylphosphine)](allyl-η3)palladium(II) chloride; tetrabutylammomium bromide; potassium acetate; palladium diacetate; caesium carbonate; acetic acid; triethylamine;
In
tetrahydrofuran; dichloromethane; Isopropyl acetate; water; ethyl acetate; toluene;
2.1: |Miyaura Borylation Reaction / 3.1: |Suzuki Coupling;
DOI:10.1021/acs.oprd.1c00237
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ethyl acetate / Industrial scale
2.1: ethyl acetate; tetrahydrofuran / 2 h / 20 °C / Industrial scale
3.1: acetic acid / ethyl acetate; tetrahydrofuran / 8 - 69 °C / Industrial scale
4.1: potassium acetate; [2,6-bis(2,4,6-triisopropylphenyl)phenyl(dicyclohexylphosphine)](allyl-η3)palladium(II) chloride / Isopropyl acetate / 5 h / 90 °C / Industrial scale
5.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tetrabutylammomium bromide; caesium carbonate / water; toluene / 17 h / 90 °C / Inert atmosphere; Industrial scale
6.1: dichloromethane / 11 h / 20 - 35 °C / Reflux; Industrial scale
7.1: triethylamine / dichloromethane / 0.5 h / 10 °C / Industrial scale
7.2: 3.5 h / 10 - 25 °C / Industrial scale
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; [2,6-bis(2,4,6-triisopropylphenyl)phenyl(dicyclohexylphosphine)](allyl-η3)palladium(II) chloride; tetrabutylammomium bromide; potassium acetate; palladium diacetate; caesium carbonate; acetic acid; triethylamine;
In
tetrahydrofuran; dichloromethane; Isopropyl acetate; water; ethyl acetate; toluene;
4.1: |Miyaura Borylation Reaction / 5.1: |Suzuki Coupling;
DOI:10.1021/acs.oprd.1c00237
