(2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

Base Information

Chemical Name:(2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate
CAS No.:1415119-50-4
Molecular Formula:C₂₀H₂₈BrN₃O₃
Molecular Weight:438.365
Hs Code.:

Synonyms:(2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

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Chemical Property of (2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

Chemical Property:

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Technology Process of (2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

There total 6 articles about (2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 109523-13-9
(2S,3aS,7aS)-1-(tert-butoxycarbonyl)octahydro-1H-indole-2-carboxylic acid

: 1415120-51-2
(2S,3aS,7aS)-tert-butyl 2-((2-amino-4-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

: 1415119-50-4
(2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1415119-50-4
(2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate / Industrial scale

2: ethyl acetate; tetrahydrofuran / 2 h / 20 °C / Industrial scale

3: acetic acid / ethyl acetate; tetrahydrofuran / 0.5 h / 8 - 13 °C / Industrial scale

With acetic acid; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/acs.oprd.1c00237

Reference yield:

: 109523-13-9
(2S,3aS,7aS)-1-(tert-butoxycarbonyl)octahydro-1H-indole-2-carboxylic acid

: 1415119-50-4
(2S,3aS,7aS)-tert-butyl 2-((2-amino-5-bromophenyl)carbamoyl)octahydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate; tetrahydrofuran / 2 h / 20 °C / Industrial scale

2: acetic acid / ethyl acetate; tetrahydrofuran / 0.5 h / 8 - 13 °C / Industrial scale

With acetic acid; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/acs.oprd.1c00237