1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE

Base Information

• Chemical Name: 1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE
• CAS No.: 1003560-58-4
• Molecular Formula: C15H20FNO3
• Molecular Weight: 281.327
• Mol file: 1003560-58-4.mol

Synonyms:1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE;tert-butyl 3-(4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate

Chemical Property of 1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE

Chemical Property:

• PSA: 49.77000
• LogP: 2.59200

Purity/Quality:

95+% ^*data from raw suppliers

tert-butyl3-(4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE

There total 2 articles about 1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) + 1-Bromo-4-fluorobenzene (460-00-4) → tert-butyl 3-(4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate (1003560-58-4)

Guidance literature:

1-Bromo-4-fluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -60 ℃; for 0.583333h; Inert atmosphere;

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/acs.joc.0c00986

Reference yield:

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) + 4-flourophenylmagnesium bromide (352-13-6) → tert-butyl 3-(4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate (1003560-58-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.583333h;

Reference yield: 53.0%

tert-butyl 3-(4-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate (1003560-58-4) → tert-butyl (3-(4-fluorophenyl)-3-oxopropyl)carbamate

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In water; 1,2-dichloro-ethane; at 20 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c00986

upstream raw materials:

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

4-flourophenylmagnesium bromide

1-Bromo-4-fluorobenzene

Downstream raw materials:

3-(4-fluorophenyl)pyrrolidine-3-ol hydrochloride

3-(4-fluorophenyl)-2,5-dihydro-1H-pyrrole hydrochloride

Refernces

• 1、 -. "SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF 11BETA-HSD-1". Page/Page column 96. . Retrieved 2008/06/13.