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352-13-6

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352-13-6 Usage

Chemical Properties

clear yellow to red-brown solution

Uses

Different sources of media describe the Uses of 352-13-6 differently. You can refer to the following data:
1. 4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.
2. 4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:Useful key intermediate in the synthesis of paroxetine.Arylsulfides via cross-coupling reaction with thiols.4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.Grignard intermediate for preparing aprepitant.

Check Digit Verification of cas no

The CAS Registry Mumber 352-13-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 352-13:
(5*3)+(4*5)+(3*2)+(2*1)+(1*3)=46
46 % 10 = 6
So 352-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1/rC6H4FMg.BrH/c7-5-1-3-6(8)4-2-5;/h1-4H;1H/q+1;/p-1

352-13-6 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (F0673)  4-Fluorophenylmagnesium Bromide (ca. 19% in Tetrahydrofuran, ca. 1.0mol/L)  

  • 352-13-6

  • 250g

  • 920.00CNY

  • Detail
  • Alfa Aesar

  • (H51169)  4-Fluorophenylmagnesium bromide, 1M in MeTHF   

  • 352-13-6

  • 100ml

  • 424.0CNY

  • Detail
  • Alfa Aesar

  • (H51169)  4-Fluorophenylmagnesium bromide, 1M in MeTHF   

  • 352-13-6

  • 500ml

  • 1629.0CNY

  • Detail
  • Aldrich

  • (328820)  4-Fluorophenylmagnesiumbromidesolution  1.0 M in THF

  • 352-13-6

  • 328820-100ML

  • 535.86CNY

  • Detail
  • Aldrich

  • (328820)  4-Fluorophenylmagnesiumbromidesolution  1.0 M in THF

  • 352-13-6

  • 328820-800ML

  • 2,292.03CNY

  • Detail

352-13-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name magnesium,fluorobenzene,bromide

1.2 Other means of identification

Product number -
Other names p-Fluorophenylmagnesium bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:352-13-6 SDS

352-13-6Relevant articles and documents

Processes for the Preparation of Zuclomiphene and Intermediates Thereof

-

Paragraph 0137-0138, (2021/05/21)

The present invention provides processes for the preparation of zuclomiphene, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the carbometallation of diphenylacetylene with a compound of Formula (3) to afford either zuclomiphene or an intermediate which is converted to zuclomiphene.

Design, synthesis and antifungal activity of novel selenochroman-4-one derivatives

Xu, Hang,Hu, Yu-Kun,Guo, Meng-Bi,Huang, Ai-Su,Su, Xin,Guo, Chun

, p. 2455 - 2463 (2017/10/06)

A series of novel selenochroman-4-one derivatives bearing semicarbazone or nitrogen heterocycle was designed, synthesized, tested antifungal activity and characterized via 1H-NMR, 13C-NMR, and HRMS. The design of the compounds is based on the principle of molecule hybrid and bioisosterism. We aimed at attaching semicarbazones or nitrogen heterocycle to the selenochroman-4-one for enhancing antifungal activity. The antifungal activity of target compounds was evaluated using the microdilution broth method in vitro test. Bioassay results indicated that some of the derivatives displayed good fungistatic activity on Candida zeylanoides, Candida albicans, Cryptococcus neoformans, resistant to fluconazole strain 103 (Candida albicans), resistant to fluconazole strain 100 (Candida albicans) and strain SC5314 (Candida albicans). All the compounds exhibit antifungal activities against the tested funguses in different levels, among them, 7 compounds of antifungal activity against several funguses is better than that of the control drug fluconazole. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.

Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates

Eno, Meredith S.,Lu, Alexander,Morken, James P.

supporting information, p. 7824 - 7827 (2016/07/11)

Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.

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