Diethyl 1-Boc-azetidine-3...

Base Information

• Chemical Name: Diethyl 1-Boc-azetidine-3...
• CAS No.: 1011479-75-6
• Molecular Formula: C₁₄H₂₃NO₆
• Molecular Weight: 301.34
• Mol file: 1011479-75-6.mol

Synonyms:Diethyl 1-Boc-azetidine-3...;Diethyl 1-Boc-azetidine-3-dicarboxylate;1-tert-butyl 3,3-diethyl azetidine-1,3,3-tricarboxylate;Diethyl 1-Boc-azetidine-3,3-dicarboxylate

Chemical Property of Diethyl 1-Boc-azetidine-3...

Chemical Property:

• Boiling Point: 344.0±42.0 °C(Predicted)
• PKA: -4.45±0.40(Predicted)
• PSA: 82.14000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 1.28760

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-tert-Butyl3,3-Diethylazetidine-1,3,3-tricarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl 1-Boc-azetidine-3...

There total 3 articles about Diethyl 1-Boc-azetidine-3... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

azetidine-3,3-dicarboxylic acid diethyl ester + di-tert-butyl dicarbonate (24424-99-5) → 1-(tert-butyl) 3,3-diethyl azetidine-1,3,3-tricarboxylate (1011479-75-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + diethyl azetidine-3,3-dicarboxylate hydrochloride → 1-(tert-butyl) 3,3-diethyl azetidine-1,3,3-tricarboxylate (1011479-75-6)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 24h;

Reference yield:

3,3‐diethyl 1‐benzylazetidine‐3,3‐dicarboxylate (642411-11-8) → 1-(tert-butyl) 3,3-diethyl azetidine-1,3,3-tricarboxylate (1011479-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; hydrogenchloride; 20% palladium hydroxide-activated charcoal / water; 1,4-dioxane; ethanol / 144 h / 20 °C

2: sodium hydrogencarbonate / water; 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; water;

upstream raw materials:

di-tert-butyl dicarbonate

3,3‐diethyl 1‐benzylazetidine‐3,3‐dicarboxylate

Downstream raw materials:

azetidine-1,3,3-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester

Refernces

• 1、 -. "ANTIMICROBIAL COMPOUNDS AND METHODS". Paragraph 00311; 00312. . Retrieved 2020/07/31.
• 2、 -. "N-BIARYL (HETERO) ARYLSULPHONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY LYMPHOCYTES INTERACTIONS". Page/Page column 99. . Retrieved 2008/06/13.