5-Methoxy-3-oxo-1,2-dihydroindene-1-carboxylic acid

Base Information

• Chemical Name: 5-Methoxy-3-oxo-1,2-dihydroindene-1-carboxylic acid
• CAS No.: 137813-03-7
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.198
• DSSTox Substance ID: DTXSID80568956
• Mol file: 137813-03-7.mol

Synonyms:137813-03-7;5-methoxy-3-oxo-1,2-dihydroindene-1-carboxylic acid;2,3-DIHYDRO-5-METHOXY-3-OXO-1H-INDENE-1-CARBOXYLIC ACID;SCHEMBL14395399;DTXSID80568956;5-methoxy-3-oxo-1,2-dihydro-indene-1-carboxylic acid;5-Methoxy-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid

Chemical Property of 5-Methoxy-3-oxo-1,2-dihydroindene-1-carboxylic acid

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.05790880
• Heavy Atom Count: 15
• Complexity: 286

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(CC2=O)C(=O)O

Technology Process of 5-Methoxy-3-oxo-1,2-dihydroindene-1-carboxylic acid

There total 3 articles about 5-Methoxy-3-oxo-1,2-dihydroindene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-2,3-dihydro-1H-inden-1-one (13623-25-1) + carbon dioxide (124-38-9,18923-20-1) → 5-methoxy-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid (137813-03-7)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, then to r.t. over 4 h, 2.) THF;

Reference yield:

6-methoxy-2,3-dihydro-1H-inden-1-one (13623-25-1) → 5-methoxy-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid (137813-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: (i) nBuLi, (ii) /BRN= 1900390/

With hydrogenchloride;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3,5-Dimethoxy-1H-indene (60229-38-1) → 5-methoxy-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid (137813-03-7)

Guidance literature:

Multistep reaction; (i) nBuLi, (ii) /BRN= 1900390/;

upstream raw materials:

6-methoxy-2,3-dihydro-1H-inden-1-one

carbon dioxide

3,5-Dimethoxy-1H-indene

Downstream raw materials:

cis-6-Methoxy-3-tosyloxymethyl-1-(2-tosyloxyethyl)indan