ACT-132577

Base Information

Chemical Name:ACT-132577
CAS No.:1103522-45-7
Molecular Formula:C16H14Br2N6O4S
Molecular Weight:546.199
Hs Code.:
Mol file:1103522-45-7.mol

Synonyms:ACT-132577;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide;N-Despropyl Macitentan

Suppliers and Price of ACT-132577

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-DespropylMacitentan
5mg
$ 305.00

TRC
N-DespropylMacitentan
10mg
$ 580.00

TRC
N-DespropylMacitentan
50mg
$ 1635.00

DC Chemicals
Aprocitentan(ACT-132577) >98%
100 mg
$ 800.00

Crysdot
ACT-132577 98+%
10mg
$ 610.00

Crysdot
ACT-132577 98+%
5mg
$ 430.00

ChemScene
Aprocitentan 98.13%
100mg
$ 2520.00

ChemScene
Aprocitentan 98.13%
5mg
$ 420.00

ChemScene
Aprocitentan 98.13%
10mg
$ 600.00

Total 40 raw suppliers

Chemical Property of ACT-132577

Chemical Property:

Boiling Point:705.0±70.0 °C(Predicted)
PKA:13.56±0.60(Predicted)
PSA：150.59000
Density:1.841±0.06 g/cm3(Predicted)
LogP:4.38590
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

98% ^*data from raw suppliers

N-DespropylMacitentan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

Technology Process of ACT-132577

There total 11 articles about ACT-132577 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 5-(4-bromophenyl)-4-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-6-fluoropyrimidine

: 1103522-45-7
ACT-132577

Guidance literature:: With potassium carbonate; SULFAMIDE; In dimethyl sulfoxide; at 70 ℃; for 3h; Solvent;

Reference yield: 77.0%

: 5-(4-bromophenyl)-4-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-6-chloropyrimidine

: 1103522-45-7
ACT-132577

Guidance literature:: 5-(4-bromophenyl)-4-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-6-chloropyrimidine; With cesium fluoride; In dimethyl sulfoxide; at 70 ℃; for 2.5h;

With potassium carbonate; SULFAMIDE; In dimethyl sulfoxide; for 3h; Reagent/catalyst; Heating;