441796-09-4

Basic information

• Product Name: benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide
• Synonyms: benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide
• CAS NO: 441796-09-4
• Molecular Weight: 636.324
• Mol File: 441796-09-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide(CAS DataBase Reference)
• NIST Chemistry Reference: benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide(441796-09-4)
• EPA Substance Registry System: benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide(441796-09-4)

Safety Data

• Hazardous Substances Data: 441796-09-4(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 1246922-88-2 2-((5-bromopyrimidin-2-yl)oxy)ethan-1-ol 
• 441797-42-8 N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-benzyl-sulfamide 
• 14101-58-7 N-benzylsulfamide 
• 147000-78-0 N¹-BOC-N³-benzylsulfamide 
• 706811-25-8 5-(4-bromophenyl)-4,6-dihydroxypyrimidine 
• 146533-41-7 5-(4-bromophenyl)-4,6-dichloropyrimidine 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 441796-08-3 N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Downstream Products

• 1103522-45-7 ACT-132577 

Relevant articles and documents

PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES

The invention relates to a process for manufacturing the compound of formula I wherein R is H, (C1-C6)alkyl or benzyl, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is H, C1-C6)alkyl or benzyl, or a salt thereof, in the presence of a base, and, when X is Br or Cl, in the presence of tetra-n-butyl ammonium fluoride hydrate or cesium fluoride. The invention further relates to the compound of formula I-1 and uses thereof.

4-PYRIMIDINESULFAMIDE DERIVATIVE

The invention relates to the compound of structural formula (I) and the salts thereof. Said compound is useful as endothelin receptor antagonist. The invention further relates to a process for preparing said compound.