4-BroMo-3-fluoroindole

Base Information

• Chemical Name: 4-BroMo-3-fluoroindole
• CAS No.: 1253926-20-3
• Molecular Formula: C8H5BrFN
• Molecular Weight: 214.0344032
• Mol file: 1253926-20-3.mol

Synonyms:4-BroMo-3-fluoroindole;4-bromo-3-fluoro-1H-Indole

Chemical Property of 4-BroMo-3-fluoroindole

Chemical Property:

• PSA: 15.79000
• LogP: 3.06950

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-3-fluoroindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-3-fluoroindole

There total 2 articles about 4-BroMo-3-fluoroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.09%

4-bromo-3,3-difluoro-1,3-dihydro-2H-indol-2-one (1253926-18-9) → 4-bromo-3-fluoro-1H-indole (1253926-20-3)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 25 ℃; for 20h; Inert atmosphere;

Reference yield:

4-bromoisatin (20780-72-7) → 4-bromo-3-fluoro-1H-indole (1253926-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 54 h / 20 °C

2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 22.5 h / 0 °C

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

4-bromoisatin

4-bromo-3,3-difluoro-1,3-dihydro-2H-indol-2-one