20780-72-7Relevant articles and documents
Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors
Abdel-Rahman, Hamdy M.,Abdelmohsen, Usama Ramadan,Aboulmagd, Asmaa M.,Hassan, Hossam M.,Sayed, Ahmed M.
, p. 6752 - 6762 (2020/03/03)
Saccharomonosporine A was recently reported as a natural anti-cancer agent working through inhibition of a Proviral integration site for Moloney murine leukemia virus-1 (PIM-1) kinase. Structural bioisosteres of this natural product were synthesized and t
Indolone compound as well as preparation method and application thereof
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, (2019/04/17)
The invention relates to an indolone compound, which is 1-(4-chlorobenzyl)-3-(hydroxyimino)-4-(4-(trifluoromethyl)phenyl)-dihydroindol-2-one. The indolone compound can be used for effectively inhibiting the activity of an hTERT gene promoter; shown by a s
Inhibitor of the human telomerase reverse trancriptase (hTERT) gene promoter induces cell apoptosis via a mitochondrial-dependent pathway
Li, Yuyin,Pan, Guojun,Chen, Yue,Yang, Qian,Hao, Tiantian,Zhao, Lianbo,Zhao, Long,Cong, Yusheng,Diao, Aipo,Yu, Peng
, p. 370 - 378 (2018/01/17)
Telomerase is aberrantly expressed in many cancers and plays an important role in the development of cellular immortality and oncogenesis, which makes it a potential cancer therapeutic target for drug discovery. Here, we constructed a firefly luciferase r