1-(chloroMethyl)-4-fluoronaphthalene

Base Information

• Chemical Name: 1-(chloroMethyl)-4-fluoronaphthalene
• CAS No.: 3094-25-5
• Molecular Formula: C₁₁H₈ClF
• Molecular Weight: 194.636
• Mol file: 3094-25-5.mol

Synonyms:1-(chloroMethyl)-4-fluoronaphthalene;MFCD08582778

Chemical Property of 1-(chloroMethyl)-4-fluoronaphthalene

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 56 °C
• Boiling Point: 303.077°C at 760 mmHg
• Flash Point: 144.3°C
• PSA: 0.00000
• Density: 1.252g/cm³
• LogP: 3.71770

Purity/Quality:

99% ^*data from raw suppliers

1-(Chloromethyl)-4-fluoronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(chloroMethyl)-4-fluoronaphthalene

There total 3 articles about 1-(chloroMethyl)-4-fluoronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-fluoronaphthalen-1-yl)methanol (79996-88-6) → 1-(chloromethyl)-4-fluoronaphthalene (3094-25-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1039/d1cc05609c

Reference yield:

4-fluoro-1-naphthalenecarbaldehyde (172033-73-7) → 1-(chloromethyl)-4-fluoronaphthalene (3094-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0.5 h / 20 °C

2: thionyl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1039/d1cc05609c

Reference yield:

1-Fluoronaphthalene (321-38-0) → 1-(chloromethyl)-4-fluoronaphthalene (3094-25-5)

Guidance literature:

With hydrogenchloride; formaldehyd; phosphoric acid; acetic acid;

DOI:10.1021/jo01096a010

upstream raw materials:

1-Fluoronaphthalene

(4-fluoronaphthalen-1-yl)methanol

4-fluoro-1-naphthalenecarbaldehyde

Downstream raw materials:

(4-fluoro-[1]naphthyl)-acetonitrile

4-Fluor-naphtylessigsaeure

2-(4-fluoro-[1]naphthyl)-3c-(4-fluoro-phenyl)-acrylonitrile

2-(4-fluoro-[1]naphthyl)-3-(4-methoxy-phenyl)-acrylonitrile

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