4-Pyrimidineacetic acid ethyl ester

Base Information

• Chemical Name: 4-Pyrimidineacetic acid ethyl ester
• CAS No.: 1240606-58-9
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166
• Hs Code.: 2933599090
• Mol file: 1240606-58-9.mol

Synonyms:4-Pyrimidineacetic acid ethyl ester;ethyl 2-(pyriMidin-4-yl)acetate;Methyl 2-(pyriMidin-4-yl)acetate;PyriMidin-4-Yl-Acetic Acid Ethyl Ester

Chemical Property of 4-Pyrimidineacetic acid ethyl ester

Chemical Property:

• Boiling Point: 256℃
• PKA: 1.44±0.10(Predicted)
• Flash Point: 109℃
• PSA: 52.08000
• Density: 1.144
• LogP: 0.58220
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Ethyl2-(pyrimidin-4-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidineacetic acid ethyl ester

There total 1 articles about 4-Pyrimidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-Methylpyrimidine (3438-46-8) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-(pyrimidin-4-yl)acetate (1240606-58-9)

Guidance literature:

4-Methylpyrimidine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 0.0833333h;

Diethyl carbonate; In tetrahydrofuran; at -70 - 20 ℃; for 96h;

Reference yield: 68.0%

ethyl 2-(pyrimidin-4-yl)acetate (1240606-58-9) + 1-(phenylethynyl)-3,3-bis(trifluoromethyl)-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole → ethyl 7-phenyl-6-(phenylethynyl)pyrrolo[1,2-c]pyrimidine-5-carboxylate

Guidance literature:

With 1,10-Phenanthroline; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); silver(I) triflimide; In acetonitrile; at 50 ℃;

DOI:10.1021/acs.orglett.1c03667

Reference yield:

ethyl 2-(pyrimidin-4-yl)acetate (1240606-58-9) → 2-(4-Pyrimidyl)acetic acid (325491-53-0)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

upstream raw materials:

4-Methylpyrimidine

Diethyl carbonate

Downstream raw materials:

2-(4-Pyrimidyl)acetic acid

Refernces

• 1、 -. "SWEET FLAVOR MODIFIER". Page/Page column 88; 89. . Retrieved 2014/03/21.