1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-phenyl-

Base Information

Chemical Name:1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-phenyl-
CAS No.:951784-03-5
Molecular Formula:C15H12N4O2
Molecular Weight:280.286
Hs Code.:
Mol file:951784-03-5.mol

Synonyms:1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-phenyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-phenyl-

Chemical Property:

PSA：104.89000
LogP:3.00030

Purity/Quality:

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Technology Process of 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-phenyl-

There total 2 articles about 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: ethyl 5-(2-aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylate

: 951784-03-5
5-(2-amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; Reflux;
DOI:10.1021/jm100504d

Reference yield:

: 106157-91-9
2-Amino-4-bromoacetylpyrimidine

: 951784-03-5
5-(2-amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

1.2: 3 h / 20 °C

1.3: 20 °C

2.1: sodium hydroxide; ethanol; water / 5 h / Heating / reflux

2.2: 0 °C

With sodium hydroxide; ethanol; water; sodium hydride; In tetrahydrofuran;

Reference yield: 66.0%

: 951784-03-5
5-(2-amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid

: 100-46-9
benzylamine

: 5-(2-amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid benzylamide

Guidance literature:: 5-(2-amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 45 ℃; Inert atmosphere;

benzylamine; In ethanol; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm100504d