3-QUINOLYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 3-QUINOLYLMAGNESIUM BROMIDE
• CAS No.: 738580-61-5
• Molecular Formula: C₉H₆BrMgN
• Molecular Weight: 232.362
• Mol file: 738580-61-5.mol

Synonyms:3-QUINOLYLMAGNESIUM BROMIDE

Chemical Property of 3-QUINOLYLMAGNESIUM BROMIDE

Chemical Property:

• PSA: 12.89000
• LogP: 2.88060

Purity/Quality:

99% ^*data from raw suppliers

3-Quinolylmagnesiumbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-QUINOLYLMAGNESIUM BROMIDE

There total 1 articles about 3-QUINOLYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromoquinoline (5332-24-1) → quinolin-3-ylmagnesium bromide (738580-61-5)

Guidance literature:

3-bromoquinoline; With tert.-butyl lithium; In diethyl ether; at -75 ℃;

With magnesium bromide; In diethyl ether; at -75 - 0 ℃;

DOI:10.1016/j.tet.2003.06.001

Reference yield:

N-(2-(4-(6-(diphenylmethyleneamino)-7-(methoxy-(methyl)amino)-7-oxoheptyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide (1421703-96-9) + quinolin-3-ylmagnesium bromide (738580-61-5) → C33H40N8O*ClH

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / -20 - 0 °C / Inert atmosphere

2.1: hydrogenchloride / water; ethanol / 12 h / 20 °C

2.2: 3 h / 95 °C / pH 4.3

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

DOI:10.1002/cmdc.201200350

Reference yield:

N-(2-(4-(6-(diphenylmethyleneamino)-7-(methoxy-(methyl)amino)-7-oxoheptyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide (1421703-96-9) + quinolin-3-ylmagnesium bromide (738580-61-5) → C45H48N6O2

Guidance literature:

In tetrahydrofuran; at -20 - 0 ℃; for 4h; Inert atmosphere;

DOI:10.1002/cmdc.201200350

upstream raw materials:

3-bromoquinoline

Refernces

• 1、 Dumouchel, Sylvain,Mongin, Florence,Trécourt, Fran?ois,Quéguiner, Guy. "Synthesis and reactivity of lithium tri(quinolinyl)magnesates". . p. 8629 - 8640. Retrieved 2007/10/03.