Borane - 5-Ethyl-2-Methylpyridine CoMplex

Base Information

• Chemical Name: Borane - 5-Ethyl-2-Methylpyridine CoMplex
• CAS No.: 1014979-56-6
• Molecular Formula: C8H14BN
• Molecular Weight: 135.017
• Mol file: 1014979-56-6.mol

Synonyms:Borane - 5-Ethyl-2-Methylpyridine CoMplex;(5-Ethyl-2-Methylpyridin-1-iuM-1-yl)trihydroborate;5-Ethyl-2-Methylpyridine borane coMplex, 90%;(5-Ethyl-2-methylpyridine)trihydroborane

Chemical Property of Borane - 5-Ethyl-2-Methylpyridine CoMplex

Chemical Property:

• Refractive Index: 1.5270-1.5290
• Flash Point: 105℃
• PSA: 3.88000
• Density: 0.907 g/mL at 25 °C
• LogP: 0.24110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Borane - 5-Ethyl-2-methylpyridine Complex ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T+
• Statements: 25-26/27-34-37/38-41
• Safety Statements: 26-28-35-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for:Organometallic cross-coupling reactionsReductive amination

Technology Process of Borane - 5-Ethyl-2-Methylpyridine CoMplex

There total 2 articles about Borane - 5-Ethyl-2-Methylpyridine CoMplex which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-ethyl-2-methyl-pyridine (104-90-5) + borane-THF (14044-65-6) → 5-ethyl-2-methylpyridine borane complex (1014979-56-6)

Guidance literature:

In toluene; at 4 - 7 ℃; Product distribution / selectivity;

Reference yield:

5-ethyl-2-methyl-pyridine (104-90-5) + diborane (19287-45-7) → 5-ethyl-2-methylpyridine borane complex (1014979-56-6)

Guidance literature:

at 0 - 26 ℃; for 2.71667 - 4h; Product distribution / selectivity; Neat (no solvent);

Reference yield:

5-ethyl-2-methylpyridine borane complex (1014979-56-6) + oct-1-ene (111-66-0,25068-25-1) + acetic acid (64-19-7,77671-22-8) → C12H23BO4 + C18H37BO2 + octane (111-65-9) + triacetoxyborane (4887-24-5)

Guidance literature:

at 70 ℃; for 1 - 21h; Product distribution / selectivity;

upstream raw materials:

5-ethyl-2-methyl-pyridine

borane-THF

diborane

Downstream raw materials:

octane

triacetoxyborane

Trimethyl borate

Refernces

Reductive amination with 5-ethyl-2-methylpyridine borane

10.1016/j.tetlet.2008.06.095

The research focuses on the development and application of a new amine borane complex, 5-ethyl-2-methylpyridine borane (PEMB), for reductive amination reactions of ketones and aldehydes. The study compares PEMB to other reagents like pyridine borane (PYB) and 2-picoline borane (PICB) in terms of efficiency, cost-effectiveness, and reaction conditions. The experiments involved using PEMB in various reductive amination reactions with different aldehyde or ketone/amine pairs, employing a 2:2:1 ratio for the carbonyl, amine, and PEMB, and in some cases, without solvent to increase volume productivity and reduce waste. The reactions were typically carried out at ambient temperature, with some requiring heating to increase the rate. The study analyzed the yields and reaction times of these processes, finding that PEMB was highly effective, selective, and faster than PICB in solvent-less conditions. The analyses used included gas chromatography (GC) to determine yields and nuclear magnetic resonance (NMR) to characterize the products.

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