ETHYL 5-(2-METHYLPHENYL)-5-OXOVALERATE

Base Information

• Chemical Name: ETHYL 5-(2-METHYLPHENYL)-5-OXOVALERATE
• CAS No.: 100972-13-2
• Molecular Formula: C14H18O3
• Molecular Weight: 234.29
• Hs Code.: 2918300090
• Mol file: 100972-13-2.mol

Synonyms:ETHYL 5-(2-METHYLPHENYL)-5-OXOVALERATE

Chemical Property of ETHYL 5-(2-METHYLPHENYL)-5-OXOVALERATE

Chemical Property:

• Vapor Pressure: 3.52E-05mmHg at 25°C
• Boiling Point: 353.7°C at 760 mmHg
• Flash Point: 154.6°C
• PSA: 43.37000
• Density: 1.049g/cm³
• LogP: 2.91110

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl5-(2-methylphenyl)-5-oxovalerate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 5-(2-METHYLPHENYL)-5-OXOVALERATE

There total 4 articles about ETHYL 5-(2-METHYLPHENYL)-5-OXOVALERATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glutaric anhydride, (108-55-4) → ethyl 5-oxo-5-(2-methylphenyl)pentanoate (100972-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C

1.2: -78 - 20 °C

2.1: sulfuric acid / 7 h / Reflux

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;

DOI:10.1002/anie.201303011

Reference yield:

2-methylphenyl bromide (95-46-5) → ethyl 5-oxo-5-(2-methylphenyl)pentanoate (100972-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C

1.2: -78 - 20 °C

2.1: sulfuric acid / 7 h / Reflux

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;

DOI:10.1002/anie.201303011

Reference yield:

ethyl glutaroyl chloride (5205-39-0) → ethyl 5-oxo-5-(2-methylphenyl)pentanoate (100972-13-2)

Guidance literature:

DOI:10.1021/jo01098a021

upstream raw materials:

ethyl glutaroyl chloride

glutaric anhydride,

ethanol

5-oxo-5-(o-tolyl)pentanoic acid

Downstream raw materials:

5-o-tolyl-valeric acid

5-oxo-5-(o-tolyl)pentanoic acid

Refernces