2-chloro-5-fluoroisonicotinonitrile

Base Information

• Chemical Name: 2-chloro-5-fluoroisonicotinonitrile
• CAS No.: 1057319-20-6
• Molecular Formula: C6H2ClFN2
• Molecular Weight: 156.547
• Mol file: 1057319-20-6.mol

Synonyms:2-chloro-5-fluoroisonicotinonitrile

Chemical Property of 2-chloro-5-fluoroisonicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.74578

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-5-fluoroisonicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-5-fluoroisonicotinonitrile

There total 4 articles about 2-chloro-5-fluoroisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-5-fluoro-4-iodopyridine (884494-49-9) + copper(l) cyanide → 2-chloro-5-fluoroisonicotinonitrile (1057319-20-6)

Guidance literature:

In N,N-dimethyl-formamide; for 3h; Reflux; Inert atmosphere;

Reference yield: 78.0%

potassium cyanide + 2-chloro-4,5-difluoropyridine (511522-70-6) → 2-chloro-5-fluoroisonicotinonitrile (1057319-20-6)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield:

2-chloro-5-fluoro-4-iodopyridine (884494-49-9) + copper(I) cyanide (544-92-3) → 2-chloro-5-fluoroisonicotinonitrile (1057319-20-6)

Guidance literature:

In N,N-dimethyl-formamide; at 150 ℃; for 3h;

upstream raw materials:

2-chloro-5-fluoro-4-iodopyridine

copper(I) cyanide

2-chloro-5-fluoropyridine

2-chloro-4,5-difluoropyridine

Downstream raw materials:

tert-butyl (2-chloro-5-fluoropyridin-4-yl)methylcarbamate

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