(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

Base Information

Chemical Name:(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid
CAS No.:1516887-33-4
Molecular Formula:C26H40O4
Molecular Weight:416.5934
Hs Code.:
Mol file:1516887-33-4.mol

Synonyms:(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid;Obeticholic Acid-G;(3alpha,5beta,6E)-6-Ethylidene-3-hydroxy-7-oxocholan-24-oic acid;(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acidid;(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,Z)-6-ethylidene-3-hydroxy-10,13-diMethyl-7-oxo- hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;Obeticholic Acid N-2;Obeticholic Acid N-5;(R)-methyl 4-((3R,5S,7R,10S,13R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Suppliers and Price of (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
Cholan-24-oicacid,6-ethylidene-3-hydroxy-7-oxo-,(3α,5β,6E)- 95
10g
$ 385.00

Crysdot
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoicacid 95+%
10g
$ 673.00

Crysdot
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoicacid 95+%
5g
$ 401.00

Crysdot
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoicacid 95+%
1g
$ 134.00

Crysdot
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoicacid 95+%
250mg
$ 53.00

Chemenu
(E)-3alpha-hydroxy-6-ethylidene-7-keto-5beta-cholan-24-oicacid 95%
5g
$ 379.00

Chemenu
(E)-3alpha-hydroxy-6-ethylidene-7-keto-5beta-cholan-24-oicacid 95%
1g
$ 138.00

Total 119 raw suppliers

Chemical Property of (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

Chemical Property:

Boiling Point:573.1±43.0 °C(Predicted)
PKA:4.76±0.10(Predicted)
PSA：74.60000
Density:1.142±0.06 g/cm3(Predicted)
LogP:5.24230
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Cholan-24-oicacid,6-ethylidene-3-hydroxy-7-oxo-,(3α,5β,6E)- 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A byproduct in the synthesis of Obeticholic Acid (E899810). May be useful in the treatment of liver diseases.

Technology Process of (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

There total 12 articles about (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: C₃₂H₅₂O₄

: 1516887-33-4
(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

Guidance literature:: With quinoline; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1516887-31-2
(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid methyl ester

: 1516887-33-4
(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 49 - 53 ℃; for 2h; Temperature; Inert atmosphere;

Reference yield:

: 3α-benzoyl-6,7-dehydro-7-trimethylsiloxy-5β-cholestane-24-acid methyl ester

: 75-07-0,9002-91-9
acetaldehyde

: 1516887-33-4
(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

Guidance literature:: 3α-benzoyl-6,7-dehydro-7-trimethylsiloxy-5β-cholestane-24-acid methyl ester; acetaldehyde; With boron trifluoride; In dichloromethane; acetonitrile; at -20 - 20 ℃; for 3h; Inert atmosphere; Large scale;

With methanol; sodium hydroxide; at 10 - 40 ℃; for 5h; Large scale;