4-Chloro-3-methoxytoluene

Base Information

• Chemical Name: 4-Chloro-3-methoxytoluene
• CAS No.: 73909-16-7
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• Hs Code.: 2909309090
• NSC Number: 220096
• UNII: KR6MZG2XUB
• DSSTox Substance ID: DTXSID30224499
• Nikkaji Number: J516.976C
• Wikidata: Q83103095
• Mol file: 73909-16-7.mol

Synonyms:1-chloro-2-methoxy-4-methylbenzene;73909-16-7;4-Chloro-3-methoxytoluene;2-Chloro-5-methylanisole;1-chloro-2-methoxy-4-methyl-benzene;Benzene, 1-chloro-2-methoxy-4-methyl-;Toluene, 4-chloro-3-methoxy-;KR6MZG2XUB;NSC 220096;BRN 3237331;NSC-220096;Benzene, 1-chloro-2-methoxy-4-methyl- (9CI);2-06-00-00355 (Beilstein Handbook Reference);NSC220096;UNII-KR6MZG2XUB;3-methoxy-4-chlorotoluene;WLN: GR D1 BO1;4-Chloro -3-methoxy toluene;SCHEMBL128701;DTXSID30224499;YCA90916;MFCD01679710;2-chloro-5-methylphenyl methyl ether;ETHYL3-METHYL-4-NITROBENZOATE;AKOS006241757;2-Chloro-5-methylphenol, methyl ether;SB38516;1-Chloro-4-methyl-2-(methyloxy)benzene;AM804302;AS-54832;LS-154033;CS-0192536;FT-0703231;EN300-137954;W10409

Chemical Property of 4-Chloro-3-methoxytoluene

Chemical Property:

• Vapor Pressure: 0.261mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 211.8 °C at 760 mmHg
• Flash Point: 87.7 °C
• PSA: 9.23000
• Density: 1.105 g/cm³
• LogP: 2.65700
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 156.0341926
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

1-Chloro-2-methoxy-4-methylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)Cl)OC

Technology Process of 4-Chloro-3-methoxytoluene

There total 8 articles about 4-Chloro-3-methoxytoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-methylphenol (615-74-7) + methyl iodide (74-88-4) → 2-chloro-5-methylanisole (73909-16-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield: 100.0%

2-chloro-5-methylphenol (615-74-7) + dimethyl sulfate (77-78-1) → 2-chloro-5-methylanisole (73909-16-7)

Guidance literature:

With potassium carbonate; In acetonitrile; for 6h; Reflux;

Reference yield: 100.0%

dimethyl sulfate (77-78-1) → 2-chloro-5-methylanisole (73909-16-7)

Guidance literature:

2-chloro-5-methylphenol; With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 0.25h;

dimethyl sulfate; In DMF (N,N-dimethyl-formamide); at 20 - 70 ℃; for 19h;

upstream raw materials:

2-Methoxy-4-methylphenol

2-chloro-5-methylphenol

dimethyl sulfate

methyl iodide

Downstream raw materials:

2-methoxy-4-methyl-1-(6-methylhept-5-en-2-yl)benzene

1,8-dimethoxy-3-methyl-9,10-anthraquinone

4-chloro-3-methoxybenzoic acid

4-(bromomethyl)-1-chloro-2-methoxybenzene