3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide

Base Information

Chemical Name:3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide
CAS No.:1338320-94-7
Molecular Formula:C₁₇H₁₆N₂O₄S
Molecular Weight:344.391
Hs Code.:
UNII:T65L58FI65
Wikidata:Q27289720
Mol file:1338320-94-7.mol

Synonyms:3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide;MPT0E028

Suppliers and Price of 3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:344.08307817
Heavy Atom Count:24
Complexity:578

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C2=C1C=C(C=C2)C=CC(=O)NO)S(=O)(=O)C3=CC=CC=C3
Isomeric SMILES:C1CN(C2=C1C=C(C=C2)/C=C/C(=O)NO)S(=O)(=O)C3=CC=CC=C3
Recent ClinicalTrials:Dose-Seeking Study of MPT0E028 in Subjects With Advanced Solid Malignancies Without Standard Treatment

Technology Process of 3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide

There total 9 articles about 3-(1-(Benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₄N₂O₅S

: 1338320-94-7
3-(1-(benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyprop-2-enamide

Guidance literature:: With trifluoroacetic acid; In methanol; at 20 ℃;

Reference yield:

: 1241118-90-0
1-Benzenesulfonyl-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester

: 1338320-94-7
3-(1-(benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyprop-2-enamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: dipyridinium dichromate / dichloromethane / 20 °C / Molecular sieve

3: dichloromethane / 3 h / 20 °C

4: water; lithium hydroxide / 1,4-dioxane / 40 °C

5: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

6: trifluoroacetic acid / methanol / 20 °C

With lithium aluminium tetrahydride; dipyridinium dichromate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1011-65-0
5-methoxycarbonylindole

: 1338320-94-7
3-(1-(benzenesulfonyl)-2,3-dihydro-1H-indol-5-yl)-N-hydroxyprop-2-enamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium cyanoborohydride; acetic acid / 2 h / 0 - 20 °C

1.2: 0 °C / pH 10

2.1: pyridine / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: dipyridinium dichromate / dichloromethane / 20 °C / Molecular sieve

5.1: dichloromethane / 3 h / 20 °C

6.1: water; lithium hydroxide / 1,4-dioxane / 40 °C

7.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

8.1: trifluoroacetic acid / methanol / 20 °C

With pyridine; lithium aluminium tetrahydride; dipyridinium dichromate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;