4-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride

Base Information

• Chemical Name: 4-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride
• CAS No.: 735241-98-2
• Molecular Formula: C5H8Cl2N2
• Molecular Weight: 130.577
• Hs Code.: 2933199090
• Mol file: 735241-98-2.mol

Synonyms:4-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride;4-(Chloromethyl)-1-methylpyrazole

Chemical Property of 4-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride

Chemical Property:

• PSA: 17.82000
• LogP: 1.96090

Purity/Quality:

97% ^*data from raw suppliers

4-(chloromethyl)-1-methyl-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride

There total 3 articles about 4-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1-methyl-1H-pyrazol-4-yl)-methanol (112029-98-8) → 4-(chloromethyl)-1-methyl-1H-pyrazole (735241-98-2)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

1-methylpyrazole-4-carbaldehyde (25016-11-9) → 4-(chloromethyl)-1-methyl-1H-pyrazole (735241-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2: thionyl chloride / dichloromethane / 1 h / Cooling with ice

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane;

Reference yield:

ethyl 1-methylpyrazole-4-carboxylate (85290-80-8) → 4-(chloromethyl)-1-methyl-1H-pyrazole (735241-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 60 °C

2: thionyl chloride / dichloromethane; toluene / 1 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane; toluene;

upstream raw materials:

(1-methyl-1H-pyrazol-4-yl)-methanol

1-methylpyrazole-4-carbaldehyde

ethyl 1-methylpyrazole-4-carboxylate

Downstream raw materials:

4-[(ethylthio)methyl]-1-methyl-1H-pyrazole

C₂₄H₁₉ClF₃N₃O₃

2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-[({1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2-oxo-1,2-dihydro-4-pyridinyl}oxy)methyl]benzonitrile

(1-methyl-1H-pyrazol-4-yl)acetonitrile