([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride

Base Information

• Chemical Name: ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride
• CAS No.: 848141-14-0
• Molecular Formula: C₇H₁₀N₂O₂S*ClH
• Molecular Weight: 222.696
• Mol file: 848141-14-0.mol

Synonyms:([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride

Chemical Property of ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride

There total 4 articles about ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-(methylsulfonyl)pyridine-2-carbonitrile (848141-13-9) → 1-(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride (848141-14-0)

Guidance literature:

With hydrogenchloride; water; hydrogen; palladium 10% on activated carbon; In methanol; under 760.051 Torr;

Reference yield:

tert-butyl ((5-(methylsulfonyl)pyridin-2-yl)methyl)carbamate → 1-(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride (848141-14-0)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 12h;

Reference yield:

2-Cyano-5-bromopyridine (97483-77-7) → 1-(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride (848141-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium t-butanolate / water; acetonitrile / 16 h / 0 - 20 °C

2: acetic acid; potassium permanganate / water / 1 h / 5 - 20 °C

3: triethylamine; hydrogen / methanol / 12 h / 20 °C / 2585.81 Torr

4: hydrogenchloride / methanol / 12 h / 20 °C

With hydrogenchloride; potassium permanganate; hydrogen; acetic acid; triethylamine; sodium t-butanolate; In methanol; water; acetonitrile;

upstream raw materials:

5-(methylsulfonyl)pyridine-2-carbonitrile

2-Cyano-5-bromopyridine

5-(methylsulfanyl)pyridine-2-carbonitrile

Downstream raw materials:

6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3- (trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide