5-(Methylsulfonyl)picolinonitrile

Base Information

• Chemical Name: 5-(Methylsulfonyl)picolinonitrile
• CAS No.: 848141-13-9
• Molecular Formula: C₇H₆N₂O₂S
• Molecular Weight: 182.203
• Hs Code.: 2933399990
• Mol file: 848141-13-9.mol

Synonyms:5-methanesulfonyl-pyridine-2-carbonitrile;

Chemical Property of 5-(Methylsulfonyl)picolinonitrile

Chemical Property:

• PSA: 79.20000
• LogP: 1.43758

Purity/Quality:

99.9% ^*data from raw suppliers

5-Methanesulfonylpyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Methanesulfonylpyridine-2-carbonitrile

Technology Process of 5-(Methylsulfonyl)picolinonitrile

There total 5 articles about 5-(Methylsulfonyl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-(methylsulfanyl)pyridine-2-carbonitrile (848141-12-8) → 5-(methylsulfonyl)pyridine-2-carbonitrile (848141-13-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -15 - 20 ℃; for 2h;

Reference yield: 87.0%

sodium methansulfinate (20277-69-4) + 2-Cyano-5-bromopyridine (97483-77-7) → 5-(methylsulfonyl)pyridine-2-carbonitrile (848141-13-9)

Guidance literature:

In dimethyl sulfoxide; at 100 - 105 ℃; Product distribution / selectivity; Industry scale;

Reference yield: 50.2%

2-cyano-5-pyridinesulfonyl chloride (928139-31-5) + methyl iodide (74-88-4) → 5-(methylsulfonyl)pyridine-2-carbonitrile (848141-13-9)

Guidance literature:

2-cyano-5-pyridinesulfonyl chloride; With sodium hydrogencarbonate; sodium sulfite; In water; at 70 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

upstream raw materials:

5-(methylsulfanyl)pyridine-2-carbonitrile

sodium methansulfinate

2-Cyano-5-bromopyridine

2-cyano-5-pyridinesulfonyl chloride

Downstream raw materials:

1-(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride

C-(5-methanesulfonyl-pyridin-2-yl)-methylamine