Technology Process of 4-(2-Pyrrolidinyl)benzonitrile
There total 3 articles about 4-(2-Pyrrolidinyl)benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene; tetrahydrofuran / 0 - 23 °C
2: trifluoroacetic acid / dichloromethane / 0 - 23 °C
3: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / 1 h / 23 °C
With
bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
1: |Mitsunobu Displacement;
DOI:10.1021/acs.orglett.0c02842
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 0 - 23 °C
2: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / 1 h / 23 °C
With
bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/acs.orglett.0c02842
- Guidance literature:
-
With
bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]};
at 23 ℃;
for 1h;
DOI:10.1021/acs.orglett.0c02842
