3-(3,5-DIFLUOROPHENYL)PROPENOL

Base Information

• Chemical Name: 3-(3,5-DIFLUOROPHENYL)PROPENOL
• CAS No.: 405937-98-6
• Molecular Formula: C9H8F2O
• Molecular Weight: 170.159
• Mol file: 405937-98-6.mol

Synonyms:3-(3,5-DIFLUOROPHENYL)PROPENOL

Chemical Property of 3-(3,5-DIFLUOROPHENYL)PROPENOL

Chemical Property:

• Vapor Pressure: 0.0107mmHg at 25°C
• Boiling Point: 251.4°C at 760 mmHg
• Flash Point: 105.9°C
• PSA: 20.23000
• Density: 1.248g/cm³
• LogP: 1.97030

Purity/Quality:

97% ^*data from raw suppliers

3-(3,5-Difluorophenyl)propenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3,5-DIFLUOROPHENYL)PROPENOL

There total 4 articles about 3-(3,5-DIFLUOROPHENYL)PROPENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(trans)-3-(3,5-difluorophenyl)acrylic acid (84315-23-1) → (E)-3-(3,5-difluorophenyl)prop-2-en-1-ol (405937-98-6)

Guidance literature:

(trans)-3-(3,5-difluorophenyl)acrylic acid; With diisobutylaluminium hydride; In dichloromethane; at -78 - -30 ℃; Inert atmosphere;

With methanol; In dichloromethane; Inert atmosphere;

DOI:10.1021/jm901559e

Reference yield: 95.0%

→ (E)-3-(3,5-difluorophenyl)prop-2-en-1-ol (405937-98-6)

Guidance literature:

Reference yield:

(trans)-3-(3,5-difluorophenyl)acrylic acid (84315-23-1) + isobutyl chloroformate (543-27-1) → (E)-3-(3,5-difluorophenyl)prop-2-en-1-ol (405937-98-6)

Guidance literature:

(trans)-3-(3,5-difluorophenyl)acrylic acid; isobutyl chloroformate; With triethylamine; In tetrahydrofuran; for 1h;

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; water; In tetrahydrofuran;

upstream raw materials:

3-(3,5-difluoro-phenyl)-acrylic acid methyl ester

(trans)-3-(3,5-difluorophenyl)acrylic acid

isobutyl chloroformate

Downstream raw materials:

(2R,3R)-3-(3,5-difluorophenyl)glycidol

3-{benzyl-[(E)-3-(3,5-difluoro-phenyl)-allyl]-amino}-propionitrile

rac-1-benzyl-4-(3,5-difluoro-benzyl)-pyrrolidine-3-carbonitrile

(E)-3-(3,5-difluorophenyl)acrylaldehyde