2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI)

Base Information

Chemical Name:2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI)
CAS No.:462116-78-5
Molecular Formula:C₁₄H₁₄O₂
Molecular Weight:214.264
Hs Code.:
Mol file:462116-78-5.mol

Synonyms:2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI)

Suppliers and Price of 2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of 2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI)

There total 5 articles about 2-Cyclopenten-1-one, 5-ethylidene-2-hydroxy-3-methyl-4-phenyl-, (4R,5E)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 91299-17-1
1-(methoxymethoxy)-1,2-propadiene

: 288093-79-8
(E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one

: 74-88-4
methyl iodide

: 462116-78-5,543692-39-3
5-Eth-(E)-ylidene-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone

Guidance literature:: 1-(methoxymethoxy)-1,2-propadiene; (E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

methyl iodide; With sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -78 - -40 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; hexane; cyclohexane; at -40 - 20 ℃; for 0.25h;
DOI:10.1021/ol034309+

Reference yield:

: 288093-79-8
(E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one

: (1R,2R,5S)-2-Buta-1,2-dienyloxy-1,8,8-trimethyl-3-oxa-bicyclo[3.2.1]octane

: 462116-78-5,543692-39-3
(S)-5-Eth-(E)-ylidene-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone

: 462116-78-5,543692-39-3
(R)-5-Eth-(E)-ylidene-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone

Guidance literature:: (1R,2R,5S)-2-Buta-1,2-dienyloxy-1,8,8-trimethyl-3-oxa-bicyclo[3.2.1]octane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one; In tetrahydrofuran; hexane; at -78 - -35 ℃; for 1h;

With hydrogenchloride; 1,1,1,3',3',3'-hexafluoro-propanol; In tetrahydrofuran; hexane; 2,2,2-trifluoroethanol; at -78 - 0 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja020591o

Reference yield:

: 288093-79-8
(E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one

: (1R,2R,5S)-2-Buta-1,2-dienyloxy-1,8,8-trimethyl-3-oxa-bicyclo[3.2.1]octane

: 462116-78-5,543692-39-3
(S)-5-Eth-(E)-ylidene-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone

: 462116-78-5,543692-39-3
(R)-5-Eth-(E)-ylidene-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone

Guidance literature:: (1R,2R,5S)-2-Buta-1,2-dienyloxy-1,8,8-trimethyl-3-oxa-bicyclo[3.2.1]octane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one; In tetrahydrofuran; hexane; at -78 - -35 ℃; for 1h;

With hydrogenchloride; 1,1,1,3',3',3'-hexafluoro-propanol; In tetrahydrofuran; hexane; 2,2,2-trifluoroethanol; at -78 - 0 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja020591o