5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine

Base Information

• Chemical Name: 5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine
• CAS No.: 817623-11-3
• Molecular Formula: C31H30N2O7
• Molecular Weight: 542.588
• Mol file: 817623-11-3.mol

Synonyms:5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine

Chemical Property of 5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine

Chemical Property:

• PSA: 101.27000
• LogP: 3.59690

Purity/Quality:

97% ^*data from raw suppliers

(2R,3R,3AS,9aR)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-hydroxy-7-methyl-3,3a-dihydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6(9aH)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine

There total 6 articles about 5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

O-2,2'-cyclo-5-methyluridine (22423-26-3) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 2,2'-anhydro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl-5-methyluridine] (817623-11-3)

Guidance literature:

With pyridine; at 20 ℃;

Reference yield:

O-2,2'-cyclo-5-methyluridine (22423-26-3) + 4,4'-dimethoxytrityl chloride (40615-36-9) → C52H48N2O9 + 2,2'-anhydro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl-5-methyluridine] (817623-11-3)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

DOI:10.1021/jo7025806

Reference yield:

5-Methyluridine (1463-10-1,642082-80-2) → 2,2'-anhydro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl-5-methyluridine] (817623-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl carbonate; sodium hydrogen carbonate / dimethylformamide / 1.5 h / Heating

2: 7.80 g / pyridine / 20 °C

With pyridine; bis(phenyl) carbonate; sodium hydrogencarbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ol062937w

upstream raw materials:

O-2,2'-cyclo-5-methyluridine

4,4'-dimethoxytrityl chloride

2',3',5'-tri-O-benzoyluridine

thymin

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyluridine

2'-methylseleno-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

2'-deoxy-2'-methyltellanyl-5'-O-(4,4'-dimethoxytrityl)thymidine

2'-deoxy-2'-phenyltellanyl-5'-O-(4,4'-dimethoxytrityl)thymidine