22423-26-3Relevant articles and documents
Facile Synthesis of 5-Substituted Arabinofuranosyluracil Derivatives
Sawai, Hiroaki,Hayashi, Hidekazu,Sekiguchi, Sumie
, p. 605 - 606 (1994)
Arabinoaminooxazoline reacted readily with α-(bromomethyl)acrylate derivatives to afford the corresponding adduct.Potassium tert-butoxide- or sodium methoxide-catalyzed cyclization of the adduct gave 5-substituted 2,2'-anhydroarabinofuranosyluracil derivatives.
METHODS FOR THE PREVENTION AND TREATMENT OF MAJOR ADVERSE CARDIOVASCULAR EVENTS USING COMPOUNDS THAT MODULATE APOLIPOPROTEIN B
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Paragraph 00639, (2016/03/22)
Provided herein, for example, are methods generally relating to preventing, treating and/or managing a major adverse cardiovascular event in a subject with a disease or condition at risk for a major adverse cardiovascular event, e.g., familial hypercholesterolemia. Also provided herein are methods relating to administering to the patient a therapeutically effective amount of an antisense oligonucleotide having a nucleobase SEQ ID NO: 247 (e.g., mipomersen).
A new straightforward synthesis of 2′,3′-didehydro-2′,3′-dideoxy-2′-(2″-(trimethylsilyl)ethylthio)thymidine, key intermediate for the synthesis of 2′-substituted thionucleosides
Oliveira, Maralise P.,Franco, Lucas L.,Lima, Maria C.A.,Sim?es, Cláudia M.O.,Galdino, Suely L.,Pitta, Ivan R.,Décout, Jean-Luc,Alves, Ricardo J.
, p. 816 - 821 (2015/04/14)
We describe herein a straightforward and efficient preparation of 2′,3′-dideoxy-2′-(2″-(trimethylsilyl)ethylthio)thymidine, which allows the preparation of diverse potentially antiviral and/or anticancer nucleosides (disulfides, thiols, sulfides, thiocyanates).