5-fluoro-2-(2-phenylethynyl)benzaldehyde

Base Information

• Chemical Name: 5-fluoro-2-(2-phenylethynyl)benzaldehyde
• CAS No.: 943835-77-6
• Molecular Formula: C15H9FO
• Molecular Weight: 224.234
• Mol file: 943835-77-6.mol

Synonyms:5-fluoro-2-(2-phenylethynyl)benzaldehyde;5-Fluoro-2-(phenylethynyl)benzaldehyde

Chemical Property of 5-fluoro-2-(2-phenylethynyl)benzaldehyde

Chemical Property:

• Melting Point: 51-52 °C
• Boiling Point: 361.6±32.0 °C (760 mmHg)
• PSA: 17.07000
• Density: 1.21±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.03800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-(phenylethynyl)benzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-2-(2-Phenylethynyl)Benzaldehyde is a reagent allow access to multi-functionalized indenes.

Technology Process of 5-fluoro-2-(2-phenylethynyl)benzaldehyde

There total 2 articles about 5-fluoro-2-(2-phenylethynyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-5-fluorobenzaldehyde (94569-84-3) + phenylacetylene (536-74-3) → 5-fluoro-2-(2-phenylethynyl)benzaldehyde (943835-77-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 50 ℃; for 20h; Inert atmosphere;

DOI:10.1002/adsc.201300396

Reference yield: 79.0%

3,4-methylenedioxyphenylethyne (57134-53-9) + 2-bromo-5-fluorobenzaldehyde (94569-84-3) → 5-fluoro-2-(2-phenylethynyl)benzaldehyde (943835-77-6)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201701516

Reference yield: 93.0%

5-fluoro-2-(2-phenylethynyl)benzaldehyde (943835-77-6) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 2-fluoro-6-phenylindazolo[3,2-a]isoquinoline (1629264-24-9)

Guidance literature:

5-fluoro-2-(2-phenylethynyl)benzaldehyde; With toluene-4-sulfonic acid hydrazide; In 1,4-dioxane; at 20 ℃; for 0.5h;

With silver trifluoromethanesulfonate; In 1,4-dioxane; at 70 ℃; for 1h;

2-(trimethylsilyl)phenyl trifluoromethanesulfonate; With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; In 1,4-dioxane; acetonitrile; at 50 ℃;

DOI:10.1055/s-0033-1341102

upstream raw materials:

2-bromo-5-fluorobenzaldehyde

phenylacetylene

3,4-methylenedioxyphenylethyne

Downstream raw materials:

(S,Z)-1-benzylidene-3-ethyl-5-fluoro-1,3-dihydroisobenzofuran

2-fluoro-5-phenylbenzo[i]phenanthridine

11-butyl-2-fluoro-5-phenylbenzo[i]phenanthridine

C₁₉H₂₀FO₄P