Technology Process of Phenylacetylene-2-13C
There total 11 articles about Phenylacetylene-2-13C which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
acetophenone-β-13C;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
diethyl chlorophosphate;
In
tetrahydrofuran; hexane;
at -78 - 25 ℃;
for 0.5h;
Inert atmosphere;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 - 25 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ja501738a
- Guidance literature:
-
With
sodium amide;
In
diethyl ether; ammonia;
at -78 ℃;
for 3h;
Yield given;
DOI:10.1021/ja00330a046
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 65 percent / pyridinium chlorochromate; HIO4*2H2O / acetonitrile / 2 h
2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h
2.2: tetrahydrofuran; hexane / -78 - 20 °C
3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
3.2: aq. HCl / tetrahydrofuran; hexane
With
periodic acid; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jo070537w
