Technology Process of styrene-β-13C-α,β-trans-2H2
There total 6 articles about styrene-β-13C-α,β-trans-2H2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: PCl5 / benzene / 5 h / 0 °C
2: NaNH2 / liquid ammonia; diethyl ether / 3 h / -78 °C
3: 87 percent / D2O, benzylhexadecyldimethylammonium chloride, NaOD / CH2Cl2
4: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min
With
n-butyllithium; deuteriated sodium hydroxide; phosphorus pentachloride; water-d2; cetyldimethylbenzylammonium chloride; sodium amide;
In
diethyl ether; dichloromethane; ammonia; benzene;
DOI:10.1021/ja00330a046
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 87 percent / D2O, benzylhexadecyldimethylammonium chloride, NaOD / CH2Cl2
2: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min
With
n-butyllithium; deuteriated sodium hydroxide; water-d2; cetyldimethylbenzylammonium chloride;
In
dichloromethane;
DOI:10.1021/ja00330a046
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) tert-butyllithium / 1.) pentane, -78 deg C, 2.45 h; 2.) pentane, ether, -78 deg C, 7 h
2: PCC / CH2Cl2
3: PCl5 / benzene / 5 h / 0 °C
4: NaNH2 / liquid ammonia; diethyl ether / 3 h / -78 °C
5: 87 percent / D2O, benzylhexadecyldimethylammonium chloride, NaOD / CH2Cl2
6: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min
With
n-butyllithium; deuteriated sodium hydroxide; phosphorus pentachloride; water-d2; tert.-butyl lithium; cetyldimethylbenzylammonium chloride; sodium amide; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; ammonia; benzene;
DOI:10.1021/ja00330a046