Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)-

Base Information

Chemical Name:Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)-
CAS No.:894786-94-8
Molecular Formula:C16H24N2O5S
Molecular Weight:356.44
Hs Code.:
Mol file:894786-94-8.mol

Synonyms:Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)-

Suppliers and Price of Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)-

Chemical Property:

PSA：112.45000
LogP:1.78040

Purity/Quality:: NLT 98% ^*data from raw suppliers

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Technology Process of Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)-

There total 10 articles about Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-diMethylethyl) ester, (2R,4'R,8'aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 221040-37-5
methyl <4'R-(4'α,7'α,8'aα)>-1-(tert-butoxycarbonyl)tetrahydro-6'-oxospiro-thiazine>-4'-carboxylate

: 894786-94-8
(2R,4'R,8a'R)-1-(tert-butoxycarbonyl)-6'-oxotetrahydro-2'H-spiro[pyrrolidine-2,7'-pyrrole[2,1-b][1,3]thiazine]-4'-carboxylic acid

Guidance literature:: With potassium carbonate; In ethanol; water; at 20 ℃; for 20h;
DOI:10.1021/jm070723u

Reference yield:

: 221040-36-4
(2RS,4R)-2-<<2'-(R)-N-(tert-butoxycarbonyl)-2'-(methoxycarbonyl)pyrrolidinyl>methyl>thiazinane-4-carboxylic acid

: 894786-94-8
(2R,4'R,8a'R)-1-(tert-butoxycarbonyl)-6'-oxotetrahydro-2'H-spiro[pyrrolidine-2,7'-pyrrole[2,1-b][1,3]thiazine]-4'-carboxylic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 72h;
DOI:10.1021/jm980525q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 894786-94-8
(2R,4'R,8a'R)-1-(tert-butoxycarbonyl)-6'-oxotetrahydro-2'H-spiro[pyrrolidine-2,7'-pyrrole[2,1-b][1,3]thiazine]-4'-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Me₄NOH*5H₂O / acetonitrile / 48 h / Ambient temperature

2: diethyl ether

3: 1.) OsO₄, H₂O, 2.) aq. NaIO₄ / 1.) THF, RT, 5 min, 2.) THF, RT, overnight

4: 75 percent / aq. NaOH / aq. ethanol / Ambient temperature

5: Et₃N / dimethylformamide / 72 h / 70 °C

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; tetramethyl ammoniumhydroxide; water; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980525q