3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride

Base Information

• Chemical Name: 3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride
• CAS No.: 1009376-74-2
• Molecular Formula: C8H16ClNO2
• Molecular Weight: 193.674
• Mol file: 1009376-74-2.mol

Synonyms:3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride

Chemical Property of 3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.67830

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-Methylpiperidine-3-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride

There total 1 articles about 3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl 6-methylnicotinate (5470-70-2) → methyl 6-methylpiperidine-3-carboxylate.hydrochloride (1009376-74-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; at 80 ℃; for 21h; under 3102.97 Torr;

Reference yield: 70.5%

methyl 6-methylpiperidine-3-carboxylate.hydrochloride (1009376-74-2) + 1-(4-chlorophenyl)cyclobutane-1-carboxylic acid (50921-39-6) → (3R,6S)-Methyl 1-[1-(4-Chlorophenyl)cyclobutanecarbonyl]-6-methylpiperidine-3-carboxylate (1009376-48-0)

Guidance literature:

With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 24.7%

methyl 6-methylpiperidine-3-carboxylate.hydrochloride (1009376-74-2) + benzyl chloroformate (501-53-1,94274-21-2) → (3R,6S)-3-methyl 1-(phenylmethyl) 6-methyl-1,3-piperidinedicarboxylate (1227917-62-5) + (trans)-1-benzyl 3-methyl 6-methylpiperidine-1,3-dicarboxylate

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 12h; pH=8 - 9;

upstream raw materials:

Methyl 6-methylnicotinate

Downstream raw materials:

C₁₆H₂₁NO₄

(3R,6S)-Methyl 1-[1-(4-Chlorophenyl)cyclobutanecarbonyl]-6-methylpiperidine-3-carboxylate

(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

(3R,6S)-3-methyl 1-(phenylmethyl) 6-methyl-1,3-piperidinedicarboxylate

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