(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Base Information

Chemical Name:(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid
CAS No.:1227917-61-4
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Suppliers and Price of (3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of (3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Technology Process of (3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

There total 5 articles about (3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1227917-62-5
(3R,6S)-3-methyl 1-(phenylmethyl) 6-methyl-1,3-piperidinedicarboxylate

: 1227917-61-4
(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Guidance literature:: (3R,6S)-3-methyl 1-(phenylmethyl) 6-methyl-1,3-piperidinedicarboxylate; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

With citric acid; In water; ethyl acetate; pH=5 - 6;

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 1227917-61-4
(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 4.5 h / 20 °C / 3102.97 Torr

1.2: 15 - 25 °C

2.1: ChiralPak IC / carbon dioxide; isopropyl alcohol / Resolution of racemate; Supercritical conditions

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

With hydrogenchloride; platinum(IV) oxide; lithium hydroxide monohydrate; hydrogen; In tetrahydrofuran; methanol; carbon dioxide; water; isopropyl alcohol;
DOI:10.1021/jm101527u

Reference yield:

: cis-3-methyl 1-(phenylmethyl) 6-methyl-1,3-piperidinedicarboxylate

: 1227917-61-4
(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ChiralPak IC / carbon dioxide; isopropyl alcohol / Resolution of racemate; Supercritical conditions

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; carbon dioxide; water; isopropyl alcohol;
DOI:10.1021/jm101527u