5'-O-DMT-N4-ethyl-2'-deoxycytidine

Base Information

• Chemical Name: 5'-O-DMT-N4-ethyl-2'-deoxycytidine
• CAS No.: 195535-75-2
• Molecular Formula: C32H35N3O6
• Molecular Weight: 557.6368
• Mol file: 195535-75-2.mol

Synonyms:5'-O-(4,4'-DiMethoxytriphenylMethyl)-N4-ethyl-2'-deoxycytidine;5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-N-ethylcytidine;5'-O-DMT-2'-deoxy-N-ethyl-cytidine;5'-O-DMT-N4-ethyl-2'-deoxycytidine

Chemical Property of 5'-O-DMT-N4-ethyl-2'-deoxycytidine

Chemical Property:

• Boiling Point: 711.0±70.0 °C(Predicted)
• PKA: 13.99±0.60(Predicted)
• PSA: 107.56000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 4.18360

Purity/Quality:

99% ^*data from raw suppliers

5''-O-[Bis(4-methoxyphenyl)phenylmethyl]-2''-deoxy-N-ethylcytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-ethylcytidine is a 5’-O-(4,4'-Dimethoxytriphenylmethy) substitued derivative of the 2’-deoxy N-methyl analogue of Cytidine.

Technology Process of 5'-O-DMT-N4-ethyl-2'-deoxycytidine

There total 1 articles about 5'-O-DMT-N4-ethyl-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-N4-ethyl-cytidine (70465-61-1) → O(5')-DMT-N(4)-ethyl-dC (195535-75-2)

Guidance literature:

In pyridine; at 20 ℃;

Reference yield:

O(5')-DMT-N(4)-ethyl-dC (195535-75-2) + acetic anhydride (108-24-7) → N(4)-acetyl-O(5')-DMT-N(4)-ethyl-dC (1377950-50-9)

Guidance literature:

O(5')-DMT-N⁽⁴⁾-ethyl-dC; In N,N-dimethyl-formamide; for 0.25h; Cooling with ice;

acetic anhydride; In N,N-dimethyl-formamide; at 20 ℃; for 24.5167h;

Reference yield:

O(5')-DMT-N(4)-ethyl-dC (195535-75-2) → N(4)-acetyl-O(3')-CEP-O(5')-DMT-N(4)-ethyl-dC (1377950-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 0.25 h / Cooling with ice

1.2: 24.52 h / 20 °C

2.1: dichloromethane / 0.08 h / 20 °C

2.2: 3.5 h / 20 °C

In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-N⁴-ethyl-cytidine

Downstream raw materials:

N⁽⁴⁾-acetyl-O(5')-DMT-N⁽⁴⁾-ethyl-dC

N⁽⁴⁾-acetyl-O(3')-CEP-O(5')-DMT-N⁽⁴⁾-ethyl-dC