70465-61-1

Usage

Uses

N4-Ethyl-2’-deoxycytidine avoids self-dimerization of fluorescent DNA probes.

Upstream product

• 103931-23-3 3’,5’-bis-O-acetyl-4-thio-2’-deoxyuridine 
• 109-89-7 diethylamine 
• 32909-05-0 N⁴-acetyl-2'-deoxycytidine 
• 75-04-7 ethylamine 

Downstream Products

• 195535-75-2 O(5')-DMT-N⁽⁴⁾-ethyl-dC 
• 1377950-50-9 N⁽⁴⁾-acetyl-O(5')-DMT-N⁽⁴⁾-ethyl-dC 
• 1377950-52-1 N⁽⁴⁾-acetyl-O(3')-CEP-O(5')-DMT-N⁽⁴⁾-ethyl-dC 

Relevant academic research and scientific papers

Rapid and selective reduction of amide group by borane-amine complexes in acyl protected nucleosides

Borane-amine complexes provide an unusually fast and selective reduction of a deoxynucleoside N-acyl group to a corresponding N-alkyl group. Three different nucleosides (dG, dA, and dC) each having one of three N-protecting groups (benzoyl, isobutyryl, or acetyl) were used to prepare N-alkylated nucleosides in good yields under mild conditions. Deoxyribose O-acyl protecting groups remain intact at the conditions of N-acyl group reduction.

Transformations of thiopyrimidine and thiopurine nucleosides following oxidation with dimethyldioxirane

A general and convenient method for the synthesis of several pyrimidine and purine nucleosides by selective oxidation of thionucleosides with dimethyldioxirane is reported. Thioketo moieties in the C-4 position of the pyrimidine ring, and in the C-6, and C-8 positions of the purine ring are the domain of oxidative nucleophilic substitution. Thioketo moieties in the C-2 position of both purine and pyrimidine rings are the domain of desulfurization or formation of disulfides.