Methyl 3-(tert-butoxycarbonyl)furan-2-carboxylate

Base Information

• Chemical Name: Methyl 3-(tert-butoxycarbonyl)furan-2-carboxylate
• CAS No.: 956034-03-0
• Molecular Formula: C11H14O5
• Molecular Weight: 241.244
• Hs Code.: 2932190090
• Mol file: 956034-03-0.mol

Synonyms:Methyl 3-(tert-butoxycarbonyl)furan-2-carboxylate;Methyl 3-((tert-butoxycarbonyl)aMino)furan-2-carboxylate

Chemical Property of Methyl 3-(tert-butoxycarbonyl)furan-2-carboxylate

Chemical Property:

• Boiling Point: 301.0±27.0 °C(Predicted)
• PKA: 12.91±0.70(Predicted)
• PSA: 81.26000
• Density: 1.211±0.06 g/cm3(Predicted)
• LogP: 2.42680
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-((tert-butoxycarbonyl)amino)furan-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-(tert-butoxycarbonyl)furan-2-carboxylate

There total 3 articles about Methyl 3-(tert-butoxycarbonyl)furan-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(3-furyl)carbamic acid tert-butyl ester (56267-48-2) + carbonic acid dimethyl ester (616-38-6) → methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylate (956034-03-0)

Guidance literature:

N-(3-furyl)carbamic acid tert-butyl ester; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -30 - 0 ℃; for 1h;

carbonic acid dimethyl ester; In tetrahydrofuran; at -30 - 0 ℃; for 0.75h;

Reference yield: 51.0%

carbonic acid dimethyl ester (616-38-6) → methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylate (956034-03-0)

Guidance literature:

N-(3-furyl)carbamic acid tert-butyl ester; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -30 - 0 ℃; for 1h;

carbonic acid dimethyl ester; In tetrahydrofuran; hexane; at -30 - 20 ℃; for 1h;

Reference yield:

methyl 3-aminofuran-2-carboxylate (956034-04-1) + di-tert-butyl dicarbonate (24424-99-5) → methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylate (956034-03-0)

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1021/acs.jmedchem.5b00910

upstream raw materials:

carbonic acid dimethyl ester

N-(3-furyl)carbamic acid tert-butyl ester

methyl 3-aminofuran-2-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

methyl 3-aminofuran-2-carboxylate

furo[3,2-d]pyrimidine-2,4-diol

2,4-dichloro-furo[3,2-d]pyrimidine

methyl 3-ureidofuran-2-carboxylate