2,4-DICHLOROFURO[3,2-D]PYRIMIDINE

Base Information

• Chemical Name: 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE
• CAS No.: 956034-07-4
• Molecular Formula: C6H2Cl2N2O
• Molecular Weight: 189.001
• Hs Code.: 2934999090
• Mol file: 956034-07-4.mol

Synonyms:2,4-DICHLOROFURO[3,2-D]PYRIMIDINE;2,4-Dichlorofuro[3,2-d]py...;4-dichlorofuro[3

Chemical Property of 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE

Chemical Property:

• Refractive Index: 1.646
• PKA: -1.02±0.40(Predicted)
• PSA: 38.92000
• Density: 1.619 g/cm³
• LogP: 2.52960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichlorofuro[3,2-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichlorofuro[3,2-d]pyrimidine is a furopyrimidine derivative used in the preparation of phosphoinositide 3-kinase inhibitor.

Technology Process of 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE

There total 6 articles about 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

furo[3,2-d]pyrimidine-2,4(1H,3H)-dione (956034-06-3) → 2,4-dichloro-furo[3,2-d]pyrimidine (956034-07-4)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 130 ℃; for 2h;

Reference yield: 85.5%

→ 2,4-dichloro-furo[3,2-d]pyrimidine (956034-07-4)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 110 ℃; for 5h;

Reference yield: 54.0%

furo[3,2-d]pyrimidine-2,4-diol (956034-06-3) → 2,4-dichloro-furo[3,2-d]pyrimidine (956034-07-4)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 130 ℃; for 3h;

upstream raw materials:

furo[3,2-d]pyrimidine-2,4-diol

furo[3,2-d]pyrimidine-2,4(1H,3H)-dione

methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylate

methyl 3-aminofuran-2-carboxylate

Downstream raw materials:

2-chloro-4-morpholinofuro[3,2-d]pyrimidine

methyl 3-(2-chlorofuro[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxylate

3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxylic acid

N-cyclobutyl-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

Refernces

• 1、 -. "PARP-1/PI3K double-target inhibitor or pharmaceutically acceptable salt thereof, preparation method and application thereof". Paragraph 0157; 0162-0164; 0175; 0181-0182. . Retrieved 2021/07/01.
• 2、 -. "Five-And-Six-Membered Heterocyclic Compound, And Preparation Method, Pharmaceutical Composition And Use Thereof". Paragraph 0240; 0246. . Retrieved 2015/12/07.