3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[[4-(trifluoromethyl)phenyl]methyl]amino]carbonyl]butyl]-

Base Information

Chemical Name:3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[[4-(trifluoromethyl)phenyl]methyl]amino]carbonyl]butyl]-
CAS No.:929611-17-6
Molecular Formula:C₂₄H₂₅F₃N₆O₂
Molecular Weight:486.497
Hs Code.:
Mol file:929611-17-6.mol

Synonyms:3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[[4-(trifluoromethyl)phenyl]methyl]amino]carbonyl]butyl]-

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Chemical Property of 3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[[4-(trifluoromethyl)phenyl]methyl]amino]carbonyl]butyl]-

Chemical Property:

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Technology Process of 3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[[4-(trifluoromethyl)phenyl]methyl]amino]carbonyl]butyl]-

There total 5 articles about 3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[[4-(trifluoromethyl)phenyl]methyl]amino]carbonyl]butyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₄F₃N₇O₄

: 929611-17-6
isoquinoline-3-carboxylic acid [4-guanidino-1-(4-trifluoromethyl-benzylcarbamoyl)-butyl]-amide

Guidance literature:: With hydrogen; Pd-BaSO₄; In methanol; acetic acid;
DOI:10.1016/j.bmcl.2006.10.056

Reference yield:

: 929611-05-2
C₁₄H₁₉F₃N₆O₃

: 929611-17-6
isoquinoline-3-carboxylic acid [4-guanidino-1-(4-trifluoromethyl-benzylcarbamoyl)-butyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: EDCl; HOBt; NMM / dimethylformamide

2: H₂ / Pd/BaSO₄ / methanol; acetic acid

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Pd-BaSO₄; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.056

Reference yield:

: C₁₉H₂₇F₃N₆O₅

: 929611-17-6
isoquinoline-3-carboxylic acid [4-guanidino-1-(4-trifluoromethyl-benzylcarbamoyl)-butyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂

2: EDCl; HOBt; NMM / dimethylformamide

3: H₂ / Pd/BaSO₄ / methanol; acetic acid

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; Pd-BaSO₄; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.056