5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine]

Base Information

Chemical Name:5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine]
CAS No.:71916-97-7
Molecular Formula:C12H15Cl2NO
Molecular Weight:223.702
Hs Code.:2934999090
DSSTox Substance ID:DTXSID00508410
Wikidata:Q72459439
Mol file:71916-97-7.mol

Synonyms:71916-97-7;5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine];SPIRO[BENZOFURAN-2(3H),4'-PIPERIDINE], 5-CHLORO-;5-Chloro-3H-spiro[benzofuran-2,4'-piperidine];5-chlorospiro[3H-1-benzofuran-2,4'-piperidine];spiro[benzofuran-2(3H),1/'-Methyl-4/'-piperidine] hydrobroMide;starbld0012429;SCHEMBL1787224;DTXSID00508410;BDYDBRINEAMBRZ-UHFFFAOYSA-N

Suppliers and Price of 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine]

Chemical Property:

PSA：21.26000
LogP:2.72590
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:223.0763918
Heavy Atom Count:15
Complexity:240

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC12CC3=C(O2)C=CC(=C3)Cl

Technology Process of 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine]

There total 10 articles about 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 644967-79-3
5-chlorospiro[1-benzofuran-2,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester

: 71916-97-7
5-chloro-2,3-dihydrospiro

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 - 50 ℃; for 22h;

Reference yield:

: 1003567-30-3
5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt

: 71916-97-7
5-chloro-2,3-dihydrospiro

Guidance literature:: With ammonia; In water; toluene; for 0.5h;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 71916-97-7
5-chloro-2,3-dihydrospiro

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg / 1.) iodine / 1.) ether, reflux, 20 h; 2.) ether, r.t., 2 h

2: 81 percent / 50percent sodium hydride (oil dispersion) / benzene; dimethylformamide / 4 h / Heating

3: 1.) ethyl chloroformate; 2.) 50percent KOH / 1.) benzene, reflux, 24 h; 2.) ethanol, reflux, 18 h

With potassium hydroxide; chloroformic acid ethyl ester; sodium hydride; magnesium; iodine; In N,N-dimethyl-formamide; benzene;