spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)

Base Information

• Chemical Name: spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)
• CAS No.: 1003567-30-3
• Molecular Formula: C12H15BrClNO
• Molecular Weight: 304.614
• Mol file: 1003567-30-3.mol

Synonyms:5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromide;5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt;5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt;5-chloro-3H-spiro[benzofuran-2,4'-piperidine] hydrobromic acid salt;SPIRO[BENZOFURAN-2(3H),4'-PIPERIDINE],5-CHLORO-,HYDROBROMIDE (1:1);5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromide;5-chloro-3H-spiro[benzofuran-2,4'-piperidine] hydrobromide;

Chemical Property of spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)

Chemical Property:

• PSA: 21.26000
• LogP: 3.68400

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)

There total 1 articles about spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

4-(5-chloro-2-methoxy-benzyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (1003567-08-5) → 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt (1003567-30-3)

Guidance literature:

With water; hydrogen bromide; acetic acid; at 40 ℃; for 7.16 - 9.33h; Heating / reflux;

Reference yield: 72.1%

2-(2-chloro-4-methylcarbamoyl-5-((S)-oxiran-2-ylmethoxy)phenoxy)-2-methylpropionic acid tert-butyl ester (1003567-16-5) + 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt (1003567-30-3) → 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester (1003567-17-6)

Guidance literature:

5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-(2-chloro-4-methylcarbamoyl-5-((S)-oxiran-2-ylmethoxy)phenoxy)-2-methylpropionic acid tert-butyl ester; In ethanol; at 20 - 50 ℃; for 8 - 9h;

Reference yield:

5-chloro-4-(4-methoxybenzyloxy)-N-methyl-2-((2S)-oxiran-2-ylmethoxy)benzamide (1003567-10-9) + 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt (1003567-30-3) → 5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-(p-methoxybenzyloxy)-N-methylbenzamide (1003567-11-0)

Guidance literature:

5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt; With ammonium hydroxide; In water; toluene; for 0.5h;

5-chloro-4-(4-methoxybenzyloxy)-N-methyl-2-((2S)-oxiran-2-ylmethoxy)benzamide; In toluene; at 80 ℃; for 22h;

upstream raw materials:

4-(5-chloro-2-methoxy-benzyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

5-chloro-2,3-dihydrospiro

2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-(p-methoxybenzyloxy)-N-methylbenzamide

Refernces

• 1、 -. "A PROCESS FOR THE PREPARATION OF INTERMEDIATES AND THEIR US IN THE SYNTHESIS OF SPIROPIPERIDINE COMPOUNDS". Page/Page column 20-21. . Retrieved 2009/03/07.