Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

Base Information

Chemical Name:Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-
CAS No.:254750-83-9
Molecular Formula:C30H35F4N3O7
Molecular Weight:625.617
Hs Code.:
Mol file:254750-83-9.mol

Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

Synonyms:Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

Suppliers and Price of Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Pentanoicacid,3-[[(2S)-2-[[2-[[2-(1,1-dimethylethyl)phenyl]amino]-2-oxoacetyl]amino]-1-oxopropyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-,1,1-dimethylethylester,(3S)-
50mg
$ 1210.00

Total 5 raw suppliers

Chemical Property of Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

Chemical Property:

PKA:11.14±0.46(Predicted)
PSA：143.39000
Density:1.287±0.06 g/cm3(Predicted)
LogP:5.15260

Purity/Quality:

≥95% ^*data from raw suppliers

Pentanoicacid,3-[[(2S)-2-[[2-[[2-(1,1-dimethylethyl)phenyl]amino]-2-oxoacetyl]amino]-1-oxopropyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-,1,1-dimethylethylester,(3S)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)-

There total 15 articles about Pentanoic acid, 3-[[(2S)-2-[[2-[[2-(1,1-diMethylethyl)phenyl]aMino]-2-oxoacetyl]aMino]-1-oxopropyl]aMino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-, 1,1-diMethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 254750-82-8
(3S)-3-[N-(N′-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

: 254750-83-9
(3S)-3-[N-(N′-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-oxopentanoic acid tert-butyl ester

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm050307e

Reference yield:

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: C₂₀H₂₁ClF₄N₂O₇

: 254750-83-9
(3S)-3-[N-(N′-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-oxopentanoic acid tert-butyl ester

Guidance literature:: With trimethylamine; In acetonitrile; at 60 ℃; for 2.16667h; Reagent/catalyst; Temperature;

Reference yield:

: 868565-55-3
(3S)-3-[(N-benzyloxycarbonyl)-L-alaninyl]amino-5-bromo-4-oxopentanoic acid tert-butyl ester

: 254750-83-9
(3S)-3-[N-(N′-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-oxopentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: KF / dimethylformamide / 4 h / 20 °C

2.1: 0.142 g / NaBH₄ / methanol; tetrahydrofuran / 1 h / 0 °C

3.1: H₂ / Pd/C / methanol / 2 h / 760 Torr

4.1: hydroxybenzotriazole hydrate; 1-ethyl-3-(3',3'-dimethyl-1'-aminopropyl)carbodiimide*HCl / CH₂Cl₂ / 0.17 h / 0 °C

4.2: N-methylmorpholine / CH₂Cl₂ / 16 h / 20 °C

5.1: 77 percent / iodobenzene diacetate; 2,2,6,6-tetramethyl-1-piperidinyloxy free radical / CH₂Cl₂ / 16 h / 20 °C

With potassium fluoride; sodium tetrahydroborate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050307e