Technology Process of D-glycero-Pentonic acid, 2,3-dideoxy-3-[[(2S)-1-oxo-2-[[(phenylMethoxy)carbonyl]aMino]propyl]aMino]-5-O-(2,3,5,6-tetrafluorophenyl)-, 1,1-diMethylethyl ester, (4ξ)- (9CI)
There total 12 articles about D-glycero-Pentonic acid, 2,3-dideoxy-3-[[(2S)-1-oxo-2-[[(phenylMethoxy)carbonyl]aMino]propyl]aMino]-5-O-(2,3,5,6-tetrafluorophenyl)-, 1,1-diMethylethyl ester, (4ξ)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
tetrahydrofuran; methanol;
at 0 ℃;
for 1h;
DOI:10.1021/jm050307e
- Guidance literature:
-
With
2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine;
In
ethyl acetate;
at 25 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bis(trimethylsilyl)trifluoroacetamide / dimethylformamide / 0.5 h / 20 °C
1.2: 82 percent / dimethylformamide / 18 h / 20 °C
2.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -10 °C
2.2: tetrahydrofuran; diethyl ether / 0.75 h / 0 - 20 °C
3.1: aq. HBr; AcOH / tetrahydrofuran; diethyl ether / 0.75 h / 0 - 20 °C
4.1: KF / dimethylformamide / 4 h / 20 °C
5.1: 0.142 g / NaBH4 / methanol; tetrahydrofuran / 1 h / 0 °C
With
4-methyl-morpholine; potassium fluoride; sodium tetrahydroborate; bis(trimethylsilyl)trifluoroacetamide; hydrogen bromide; acetic acid; isobutyl chloroformate;
In
tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm050307e
![(3S)-3-[(N-benzyloxycarbonyl)alaninyl]amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-oxopentanoic acid tert-butyl ester](/Databaselist/images/loading.webp)
