11α,12α-Epoxy-3β,13-dihydroxyoleanane-28-oic acid γ-lactone

Base Information

• Chemical Name: 11α,12α-Epoxy-3β,13-dihydroxyoleanane-28-oic acid γ-lactone
• CAS No.: 19897-41-7
• Molecular Formula: C30H46O4
• Molecular Weight: 470.68
• Mol file: 19897-41-7.mol

Synonyms:(+)-3β,13-Dihydroxy-11α,12α-epoxyoleanane-28-oic acid 28,13-lactone;11α,12α-Epoxy-3β,13-dihydroxyoleanane-28-oic acid γ-lactone

Chemical Property of 11α,12α-Epoxy-3β,13-dihydroxyoleanane-28-oic acid γ-lactone

Chemical Property:

• Vapor Pressure: 7.3E-16mmHg at 25°C
• Boiling Point: 579.9°C at 760 mmHg
• PKA: 15.16±0.70(Predicted)
• Flash Point: 184.2°C
• PSA: 59.06000
• Density: 1.17g/cm³
• LogP: 5.89550

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11α,12α-Epoxy-3β,13-dihydroxyoleanane-28-oic acid γ-lactone

There total 7 articles about 11α,12α-Epoxy-3β,13-dihydroxyoleanane-28-oic acid γ-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3β-hydroxyolean-11-en-13β,28-olide (84164-78-3) → 3β-hydroxy-11α,12α-epoxy-olean-28,13β-olide (19897-41-7)

Guidance literature:

With dihydrogen peroxide; toluene-4-sulfonic acid; at 25 ℃; for 10h;

Reference yield:

erythrodiol (545-48-2,55869-95-9,118204-21-0) → 3β-hydroxy-11α,12α-epoxy-olean-28,13β-olide (19897-41-7)

Guidance literature:

With selenium(IV) oxide; dihydrogen peroxide; In tert-butyl alcohol; for 60h; Heating;

DOI:10.1016/S0040-4020(01)90326-6

Reference yield:

Oleanolic acid (508-02-1) → 3β-hydroxy-11α,12α-epoxy-olean-28,13β-olide (19897-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / acetic acid; methanol / 8 h / glassy carbon electrode, current density 2.5 mA/cm², 25-35 V

2: 80 percent / 30percent aq. H₂O₂, p-toluenesulfonic acid / 10 h / 25 °C

With dihydrogen peroxide; toluene-4-sulfonic acid; In methanol; acetic acid;

upstream raw materials:

oleanolic acid 3-acetate

erythrodiol

(4aS,6aS,6bR,10S,12aR)-methyl 10-acetoxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate

3β-hydroxyolean-11-en-13β,28-olide

Downstream raw materials:

11α,12α-epoxy-oleanan-28->13-olide-3β-yl acetate