[S-(R*,R*)]-1-[1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperdinecarboxylic acid

Base Information

• Chemical Name: [S-(R*,R*)]-1-[1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperdinecarboxylic acid
• CAS No.: 195202-09-6
• Molecular Formula: C₁₉H₂₇NO₆
• Molecular Weight: 365.426
• Mol file: 195202-09-6.mol

Synonyms:[S-(R*,R*)]-1-[1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperdinecarboxylic acid;(2R)-1-(2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylic acid

Chemical Property of [S-(R*,R*)]-1-[1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperdinecarboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [S-(R*,R*)]-1-[1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperdinecarboxylic acid

There total 11 articles about [S-(R*,R*)]-1-[1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperdinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(2S)-2-(3,4,5-trimethoxyphenyl)butanoic acid (195202-08-5) + (S)-methyl pipecolinate hydrochloride (18650-39-0) → (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylic acid (195202-09-6)

Guidance literature:

(2S)-2-(3,4,5-trimethoxyphenyl)butanoic acid; (S)-methyl pipecolinate hydrochloride; With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20 ℃; for 2h;

With lithium hydroxide; In dichloromethane; water; at 20 ℃;

Reference yield: 70.0%

(2S,3S)-3-carboxy-2,3-dihydroxypropanoic acid (S)-2-carboxypiperidinium salt + (S)-2-(3,4,5-trimethoxyphenyl)butanoyl chloride → (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylic acid (195202-09-6)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 22h; Reflux;

DOI:10.1021/acs.joc.8b00698

Reference yield: 66.0%

C20H29NO6 → (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylic acid (195202-09-6)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; water; at 22 ℃; for 12h;

upstream raw materials:

(2S)-2-(3,4,5-trimethoxyphenyl)butanoic acid

(S)-methyl pipecolinate hydrochloride

3,4,5-trimethoxyphenyl acetic acid

2-ethyl-(3,4,5-trimethoxyphenyl)acetic acid

Downstream raw materials:

AP₂₀₁₈₇

(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate